Birds demonstrate that flapping-wing flight (FWF) is a versatile flight mode, compatible with hovering, forward flight and gliding to save energy. This extended flight domain would be especially useful on mini-UAVs. However, design is challenging because aerodynamic efficiency is conditioned by complex movements of the wings, and because many interactions exist between morphological ( wing area, aspect ratio) and kinematic parameters (flapping frequency, stroke amplitude, wing unfolding). Here we used artificial evolution to optimize these morpho-kinematic features on a simulated 1 kg UAV, equipped with wings articulated at the shoulder and wrist. Flight tests were conducted in a dedicated steady aerodynamics simulator. Parameters generating horizontal flight for minimal mechanical power were retained. Results showed that flight at medium speed (10-12 m s(-1)) can be obtained for reasonable mechanical power (20 W kg(-1)), while flight at higher speed (16-20 m s(-1)) implied increased power (30-50 W kg(-1)). Flight at low speed (6-8 m s(-1)) necessitated unrealistic power levels (70-500 W kg(-1)), probably because our simulator neglected unsteady aerodynamics. The underlying adaptation of morphology and kinematics to varying flight speed were compared to available biological data on the flight of birds.