A New Physiologic Mouse Model of One Anastomosis Gastric Bypass

被引：3

作者：

Kroh, Andreas ^{[1
]}

Eickhoff, Roman M. ^{[1
]}

Heise, Daniel ^{[1
]}

Alizai, Patrick H. ^{[1
]}

Rheinwalt, Karl P. ^{[2
]}

Neumann, Ulf P. ^{[1
,3
]}

Ulmer, Florian T. ^{[1
,3
]}

机构：

[1] Univ Hosp RWTH Aachen, Dept Gen Visceral & Transplantat Surg, Pauwelsstr 30, DE-52074 Aachen, Germany

[2] St Franziskus Hosp, Dept Bariatr & Metab Surg, Cologne, Germany

[3] Maastricht Univ, Dept Surg, Med Ctr, Maastricht, Netherlands

来源：

EUROPEAN SURGICAL RESEARCH | 2018年 / 59卷 / 5-6期

关键词：

One anastomosis gastric bypass; Mini-gastric bypass; Mouse model; Bariatric surgery; INTENSIVE MEDICAL THERAPY; ROUX-EN-Y; BARIATRIC SURGERY; GLUCOSE-HOMEOSTASIS; SLEEVE GASTRECTOMY; WEIGHT-LOSS; OBESITY;

D O I：

10.1159/000493385

中图分类号：

R61 [外科手术学];

学科分类号：

摘要：

Background: One anastomosis gastric bypass (OAGB) is a modern metabolic operation that has been demonstrated to be a rapid, safe, and effective procedure. As for other bariatric operations, the mechanisms and long-term effects of this procedure remain largely unknown and are difficult to address in human studies. Here, we present a new physiologic mouse model for mechanistic and long-term investigations. Methods: Six-week-old C57Bl/6 mice were fed a high-fat diet for 12 weeks and scheduled for OAGB or sham operation. Mice were observed for 2 weeks after the operation, and weight and metabolic condition were monitored. Results: Six mice were used to adapt the surgical technique. Afterwards, another 7 mice were scheduled for OAGB without further complications. The newly established OAGB procedure resulted in significant weight loss and improvement of glucose metabolism 2 weeks after the operation. Conclusions: The operation presented here is an easy-to-learn and physiologic mouse model of OAGB that can be used for further studies in mice. (c) 2018 S. Karger AG, Basel

引用

页码：320 / 328

页数：9

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