Lithium enediolates and dienediolates of carboxylic acids in synthesis: Alkylation with secondary halides

被引：23

作者：

Brun, EM ^{[1
]}

Gil, S ^{[1
]}

Mestres, R ^{[1
]}

Parra, M ^{[1
]}

机构：

[1] Univ Valencia, Dept Quim Organ, Valencia, Spain

来源：

TETRAHEDRON | 1998年 / 54卷 / 50期

关键词：

alkylation; carboxylic acids; lithium enolates;

D O I：

10.1016/S0040-4020(98)00957-0

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

High yields in the alkylation of dianions of alpha,beta-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. alpha-Regioselectivity for the alkylation of but-2-enoic acids (1-4) is seldom obtained. Although double bond stereoselectivity is higher than 99% for gamma-alkylated products, stereoselectivity is rather poor for most of the alpha-alkylated products. (C) 1998 Elsevier Science Ltd. AII rights reserved.

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收藏

页码：15305 / 15320

页数：16

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