Kinetics and mechanism of oxidation of hexoses by bromamine-T in alkaline medium

The kinetics and mechanism of oxidation of D-glucose and D-mannose with bromamine-T in alkaline medium have been studied and the rate = k[BAT] [sugar][OH-](2), is observed. The rate of the reaction is influenced by a change in ionic strength of the medium and the dielectric effect is found to be positive. The latter enables the computation of d(AB), the size of the activated complex. Proton inventory studies are made for the reactions in H2O-D2O mixtures. Activation parameters are calculated from the Arrhenius plots. The product analyses indicates that the sugars are oxidized to a mixture of aldonic acids, consisting of arabinonic, ribonic, erythronic and glyceric acids. A mechanism consistent with the observed kinetics has been proposed.