Global guideline for the diagnosis and management of rare mould infections: an initiative of the European Confederation of Medical Mycology in cooperation with the International Society for Human and Animal Mycology and the American Society for Microbiology

被引：286

作者：

Hoenigl, Martin ^{[1
,2
,3
,57
]}

Salmanton-Garcia, Jon ^{[5
,6
]}

Walsh, Thomas J. ^{[8
,9
,10
,11
]}

Nucci, Marcio ^{[12
]}

Neoh, Chin Fen ^{[13
]}

Jenks, Jeffrey D. ^{[2
,3
,4
]}

Lackner, Michaela ^{[14
]}

Sprute, Rosanne ^{[5
,7
]}

Al-Hatmi, Abdullah M. S. ^{[15
]}

Bassetti, Matteo ^{[16
]}

Carlesse, Fabianne ^{[17
,18
]}

Freiberger, Tomas ^{[19
,20
]}

Koehler, Philipp ^{[5
,6
,7
,21
]}

Lehrnbecher, Thomas ^{[22
]}

Kumar, Anil ^{[23
]}

Prattes, Juergen ^{[1
]}

Richardson, Malcolm ^{[24
,25
]}

Revankar, Sanjay ^{[26
]}

Slavin, Monica A. ^{[27
,28
]}

Stemler, Jannik ^{[5
,7
]}

Spiess, Birgit ^{[29
]}

Taj-Aldeen, Saad J. ^{[30
]}

Warris, Adilia ^{[31
]}

Woo, Patrick C. Y. ^{[32
]}

Young, Jo-Anne H. ^{[33
]}

Albus, Kerstin ^{[5
,6
]}

Arenz, Dorothee ^{[5
,6
,34
]}

Arsic-Arsenijevic, Valentina ^{[35
,57
]}

Bouchara, Jean-Philippe ^{[36
,37
]}

Chinniah, Terrence Rohan ^{[38
]}

Chowdhary, Anuradha ^{[39
]}

de Hoog, G. Sybren ^{[41
]}

Dimopoulos, George ^{[42
]}

Duarte, Rafael F. ^{[43
]}

Hamal, Petr ^{[44
,57
]}

Meis, Jacques F. ^{[40
,41
,57
]}

Mfinanga, Sayoki ^{[45
,46
,47
,48
]}

Queiroz-Telles, Flavio ^{[49
]}

Patterson, Thomas F. ^{[50
]}

Rahav, Galia ^{[51
,52
]}

Rogers, Thomas R. ^{[53
]}

Rotstein, Coleman ^{[54
]}

Wahyuningsih, Retno ^{[55
,56
]}

Seidel, Danila ^{[5
,6
,7
]}

Cornely, Oliver A. ^{[6
,7
,57
]}

机构：

[1] Med Univ Graz, Sect Infect Dis & Trop Med, Graz, Austria

[2] Univ Calif San Diego, Div Infect Dis & Global Publ Hlth, Dept Med, San Diego, CA 92103 USA

[3] Univ Calif San Diego, Clin & Translat Fungal Res Working Grp, San Diego, CA 92103 USA

[4] Univ Calif San Diego, Dept Med, Div Gen Internal Med, San Diego, CA 92103 USA

[5] Univ Cologne, Fac Med, Cologne, Germany

[6] Univ Cologne, Cologne Excellence Cluster Cellular Stress Respon, Cologne, Germany

[7] German Ctr Infect Res, Partner site Bonn Cologne, Cologne, Germany

[8] Weill Cornell Med, Dept Med, New York, NY USA

[9] Weill Cornell Med, Dept Pediat, New York, NY USA

[10] Weill Cornell Med, Dept Microbiol & Immunol, New York, NY USA

[11] Presbyterian Hosp, Weill Cornell Med Ctr, New York, NY USA

[12] Fed Univ Rio Janeiro, Dept Internal Med, Rio De Janeiro, Brazil

[13] Univ Teknol, MARA, Pharmaceut & Life Sci Community Res, Fac Pharm & Collaborat Drug Discovery Res Grp, Selangor, Malaysia

[14] Med Univ Innsbruck, Inst Hyg & Med Microbiol, Dept Hyg Med Microbiol & Publ Hlth, Innsbruck, Austria

[15] Univ Nizwa, Dept Microbiol, Nat Med Sci Res Ctr, Nizwa, Oman

[16] Univ Genoa, IRCCS San Martino Polyclin Hosp, Dept Hlth Sci, Div Infect Dis, Genoa, Italy

[17] Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, Brazil

[18] Univ Fed Sao Paulo, Pediat Oncol Inst, IOP GRAACC UNIFESP, Sao Paulo, Brazil

[19] Masaryk Univ, Ctr Cardiovasc Surg & Transplantat, Brno, Czech Republic

[20] Masaryk Univ, Fac Med, Brno, Czech Republic

[21] Ctr Integrated Oncol Aachen, Bonn Cologne Duesseldorf, Cologne, Germany

[22] Univ Hosp, Hosp Children & Adolescents, Div Pediat Hematol & Oncol, Frankfurt, Germany

[23] Amrita Vishwa Vidyapeetham, Amrita Inst Med Sci & Res Ctr, Dept Microbiol, Kochi, Kerala, India

[24] Univ Manchester, Div Infect, Immun & Resp Med, Manchester, Lancs, England

[25] Univ NHS Fdn Manchester Trust, Mycol Reference Ctr, Manchester, Lancs, England

[26] Wayne State Univ, Div Infect Dis, Detroit, MI USA

[27] Univ Melbourne, Melbourne, Vic, Australia

[28] Peter MacCallum Canc Ctr, Natl Ctr Infect Canc, Melbourne, Vic, Australia

[29] Heidelberg Univ, Univ Hosp Mannheim, Dept Hematol & Oncol, Mannheim, Germany

[30] Hamad Med Corp, Dept Lab Med & Pathol, Doha, Qatar

[31] Univ Exeter, Med Res Council Ctr Med Mycol, Exeter, Devon, England

[32] Univ Hong Kong, Dept Microbiol, Hong Kong, Peoples R China

[33] Univ Minnesota, Minneapolis, MN 55417 USA

[34] Univ Hamburg, Med Ctr Hamburg Eppendorf, Hamburg, Germany

[35] Univ Belgrade, Fac Med, Natl Reference Lab Med Mycol, Inst Microbiol & Immunol, Belgrade, Serbia

[36] Univ Angers, Angers Univ Hosp, Host Pathogen Interact Study Grp, Angers, France

[37] Univ Angers, Angers Univ Hosp, Lab Parasitol & Mycol, Angers, France

[38] Univ Colombo, Dept Microbiol, Colombo, Sri Lanka

[39] Univ Delhi, Vallabhbhai Patel Chest Inst, Dept Med Mycol, Delhi, India

[40] Radboud Univ Nijmegen, Med Ctr, Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands

[41] Radboud Univ Nijmegen, Med Ctr, Canisius Wilhelmina Hosp, Ctr Expertise Mycol, Nijmegen, Netherlands

[42] Natl & Kapodistrian Univ, Attikon Univ Hosp, Crit Care Dept, Athens, Greece

[43] Univ Hosp Puerta Hierro Majadahonda, Madrid, Spain

[44] Palacky Univ Olomouc, Univ Hosp Olomouc, Fac Med & Dent, Dept Microbiol, Olomouc, Czech Republic

[45] Natl Inst Med Res, Dar Es Salaam, Tanzania

[46] Muhimbili Univ Hlth & Allied Sci, Dar Es Salaam, Tanzania

[47] Nelson Mandela African Inst Sci & Technol, Arusha, Tanzania

[48] Liverpool Sch of Trop Med, Dept Int, Liverpool, Merseyside, England

[49] Univ Fed Parana, Clin Hosp, Dept Publ Hlth, Curitiba, Parana, Brazil

[50] UT Hlth San Antonio & South Texas Vet Hlth Care S, San Antonio, TX USA

来源：

LANCET INFECTIOUS DISEASES | 2021年 / 21卷 / 08期

关键词：

INVASIVE SCEDOSPORIUM SPP; LOMENTOSPORA-PROLIFICANS; TRANSPLANT RECIPIENTS; FUNGAL-INFECTIONS; FUSARIUM INFECTION; ANTIFUNGAL AGENTS; CYSTIC-FIBROSIS; IMMUNOCOMPROMISED PATIENTS; CLINICAL CHARACTERISTICS; VERTEBRAL OSTEOMYELITIS;

D O I：

10.1016/S1473-3099(20)30784-2

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

With increasing numbers of patients needing intensive care or who are immunosuppressed, infections caused by moulds other than Aspergillus spp or Mucorales are increasing. Although antifungal prophylaxis has shown effectiveness in preventing many invasive fungal infections, selective pressure has caused an increase of breakthrough infections caused by Fusarium, Lomentospora, and Scedosporium species, as well as by dematiaceous moulds, Rasamsonia, Schizophyllum, Scopulariopsis, Paecilomyces, Penicillium, Talaromyces and Purpureocillium species. Guidance on the complex multidisciplinary management of infections caused by these pathogens has the potential to improve prognosis. Management routes depend on the availability of diagnostic and therapeutic options. The present recommendations are part of the One World-One Guideline initiative to incorporate regional differences in the epidemiology and management of rare mould infections. Experts from 24 countries contributed their knowledge and analysed published evidence on the diagnosis and treatment of rare mould infections. This consensus document intends to provide practical guidance in clinical decision making by engaging physicians and scientists involved in various aspects of clinical management. Moreover, we identify areas of uncertainty and constraints in optimising this management.

引用

页码：E246 / E257

页数：12

共 75 条

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