Green approach to synthesis of novel and broad-range diversity of 4-(aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine derivatives

被引：4

作者：

Morshedi, Abdollah ^{[1
]}

Shaterian, Hamid Reza ^{[1
]}

机构：

[1] Univ Sistan & Baluchestan, Fac Sci, Dept Chem, POB 98135-674, Zahedan, Iran

来源：

RESEARCH ON CHEMICAL INTERMEDIATES | 2018年 / 44卷 / 12期

关键词：

4-(Aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine; (Phenylsulfonyl)acetonitrile; Glycerol; Green chemistry; Multi-component reactions; HIGHLY EFFICIENT; ANTITUMOR AGENTS; CATALYST; ANALOGS; PYRAN;

D O I：

10.1007/s11164-018-3552-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One-pot, three-component condensation reaction between (phenylsulfonyl)acetonitrile, aromatic aldehydes, and -naphthol for preparation of 4-(aryl)-3-(phenylsulfonyl)-4H-benzo[h]chromen-2-amine derivatives has been reported. The method involves domino Knoevenagel condensation/Michael addition, and cyclization cascade. The reaction was performed in glycerol, which is a commercially available, inexpensive and non-toxic compound. High purity of the products, very high yields and wide scope of substrates are advantages of this protocol. [GRAPHICS] .

引用

页码：7219 / 7230

页数：12

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