Daily and circadian rhythms of tissue factor pathway inhibitor and factor VII activity

被引:76
作者
Pinotti, M
Bertolucci, C
Portaluppi, F
Colognesi, I
Frigato, E
Foà, A
Bernardi, F
机构
[1] Univ Ferrara, Dipartmento Biochim & Biol Mol, I-44100 Ferrara, Italy
[2] Univ Ferrara, Dept Biol, I-44100 Ferrara, Italy
[3] Univ Ferrara, Ctr Neurosci, I-44100 Ferrara, Italy
[4] Univ Ferrara, Dept Med Clin & Sperimentale, I-44100 Ferrara, Italy
关键词
factor VII; TFPI; circadian; feeding schedule; mouse model;
D O I
10.1161/01.ATV.0000153140.13148.e0
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective - Diurnal variations in levels of factor VII ( FVII), FVIII, proteins C and S, antithrombin, plasminogen activator inhibitor- 1, prothrombin fragment F1+2, and D-dimers in healthy humans point to the existence of circadian rhythms of coagulation factors. We sought for temporal fluctuations of tissue factor pathway inhibitor ( TFPI) activity in human and mouse plasma. Methods and Results - TFPI activity showed significant daily variations with highest levels in the morning in healthy men ( + 11%) and in mice at the light-to-dark transition ( + 63%), the beginning of the physically active period. Variations in FVII activity paralleled those in TFPI. In mice, the feeding schedule had a strong impact on these rhythms. Although restricted feeding and fasting shifted the peak of TFPI, the FVII peak disappeared. Investigation of temporal fluctuations in constant darkness indicated the existence of daily rhythms for TFPI and of true circadian rhythms for FVII. Conclusions - For the first time, we report, both in humans and mice, temporal variations in TFPI activity. The coherent variations in FVII and TFPI activity could interplay to maintain the coagulation equilibrium. The chronobiological patterns should be considered to analyze activity levels of these factors. Moreover, the mouse model could be exploited to investigate modifiers of coagulation rhythms potentially associated to morning peaks of cardiovascular events.
引用
收藏
页码:646 / 649
页数:4
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