A fully synthetic vaccine consisting of a tumor-associated glycopeptide antigen and a T-Cell epitope for the induction of a highly specific humoral immune response

被引：109
作者：
Dziadek, S
Hobel, A
Schmitt, E
Kunz, H
机构：
[1] Johannes Gutenberg Univ Mainz, Inst Organ Chem, D-55128 Mainz, Germany
[2] Johannes Gutenberg Univ Mainz, Inst Immunol, D-55101 Mainz, Germany
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 46期
关键词：
antigens; antitumor agents; glycopeptides; synthetic vaccines; T-cell epitope;
D O I：
10.1002/anie.200501594
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Figure Presented) On target: With the fully synthetic vaccine 1 consisting of a tumor-associated sialyl-Tn glycopeptide antigen from the epithelial mucin MUC1 and a T-cell epitope from ovalbumin, a strong, highly specific immune response (IgG) directed against the glycopeptide antigen was induced in a mouse thereby realizing the most important requirement for the development of synthetic vaccines for the initiation of the body's own immune defense against tumors. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.
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页码：7630 / 7635
页数：6
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