Coupling chromatography and crystallization for efficient separations of isomers

被引：11
作者：
Gedicke, K
Beckmann, W
Brandt, A
Sapoundjiev, D
Lorenz, H
Budde, U
Seidel-Morgenstern, A
机构：
[1] Otto von Guericke Univ, IVT, D-39106 Magdeburg, Germany
[2] Schering AG, Verfahrenstech, D-13342 Berlin, Germany
[3] Max Planck Inst Dynam Complex Tech Syst, D-39106 Magdeburg, Germany
来源：
ADSORPTION-JOURNAL OF THE INTERNATIONAL ADSORPTION SOCIETY | 2005年 / 11卷 / Suppl 1期
关键词：
chromatography; simulated moving bed process; crystallization; hybrid processes;
D O I：
10.1007/s10450-005-5990-8
中图分类号：
O64 [物理化学（理论化学）、化学物理学];
学科分类号：
070304 ; 081704 ;
摘要：
Within the pharmaceutical industry and in biotechnology there is an increasing need for selective and efficient separation technologies to isolate and purify value-added products. A hybrid process approach combining chromatography and fractional crystallization is studied below. The work presented is concerned with the application and evaluation of this concept in order to isolate a certain pharmaceutical intermediate from a binary mixture. A comparison with performing the same separation exclusively in a single chromatographic process is given also.
引用
收藏
页码：591 / 596
页数：6
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