Synthesis of functionalized indoles via cascade benzannulation strategies: a decade's overview

被引：29

作者：

Sahu, Samrat ^{[1
]}

Banerjee, Ankush ^{[1
]}

Kundu, Samrat ^{[1
]}

Bhattacharyya, Arya ^{[1
]}

Maji, Modhu Sudan ^{[1
]}

机构：

[1] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2022年 / 20卷 / 15期

关键词：

PYRROLES; ANNULATION; SCAFFOLD; REARRANGEMENT; HETEROCYCLES; ACCESS; AGENTS; ROUTE; RING;

D O I：

10.1039/d2ob00187j

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indoles are one of the most prominent aromatic heterocycles in the organic chemistry field. Due to their widespread presence in various natural products, alkaloids, drugs, approved medicines, etc. the synthesis and functionalization of indoles are of great interest. This review emphasizes recent developments and techniques in the domino cascade cyclization process in the last decade starting from the various building blocks. In particular, this review depicts several intriguing benzannulation methods of creating a benzene ring on a pre-existing pyrrole nucleus in an inter/intramolecular fashion under metal-catalyzed/metal-free approaches. Different subsections focus on gradual timely developments in this complementary area and a detailed analysis of the mechanisms and reactivity patterns. As a complementary method, this review gives a significant incentive to various annulation strategies and also gives an overview of the remaining challenges and upcoming possibilities.

引用

页码：3029 / 3042

页数：14

共 63 条

[1] Benzannulation strategies for the synthesis of carbazoles, indolocarbazoles, benzocarbazoles, and carbolines [J].