Prenatal, Early-Life, and Childhood Exposure to Air Pollution and Lung Function: The ALSPAC Cohort

被引:52
作者
Cai, Yutong [1 ,3 ,4 ]
Hansell, Anna L. [1 ,5 ]
Granell, Raquel [6 ]
Blangiardo, Marta [1 ]
Zottoli, Mariagrazia [4 ]
Fecht, Daniela [1 ]
Gulliver, John [1 ,5 ]
Henderson, A. John [6 ]
Elliott, Paul [1 ,2 ,7 ,8 ,9 ,10 ]
机构
[1] Imperial Coll London, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC Ctr Environm & Hlth, London, England
[2] Imperial Coll London, UK Dementia Res Inst, London, England
[3] Kings Coll London, MRC Ctr Environm & Hlth, Sch Populat Hlth & Environm Sci, Dept Analyt Environm & Forens Sci, London, England
[4] Univ Oxford, George Inst Global Hlth, Oxford, England
[5] Univ Leicester, Ctr Environm Hlth & Sustainabil, Leicester, Leics, England
[6] Univ Bristol, Bristol Med Sch, MRC Integrat Epidemiol Unit, Bristol, Avon, England
[7] Imperial Coll London, Imperial Biomed Res Ctr, London, England
[8] Imperial Coll NHS Healthcare Trust, London, England
[9] Natl Inst Hlth Res, Hlth Protect Res Unit Hlth Impact Environm Hazard, London, England
[10] Hlth Data Res UK London, London, England
基金
英国惠康基金; 英国医学研究理事会;
关键词
ALSPAC; children; traffic; air pollution; respiratory health; LONG-TERM EXPOSURE; PROFILE REGRESSION; CHILDREN; ASSOCIATION; PREGNANCY; PM10; AGE;
D O I
10.1164/rccm.201902-0286OC
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Rationale: Exposure to air pollution during intrauterine development and through childhood may have lasting effects on respiratory health. Objectives: To investigate lung function at ages 8 and 15 years in relation to air pollution exposures during pregnancy, infancy, and childhood in a UK population-based birth cohort. Methods: Individual exposures to source-specific particulate matter <10 mm in aerodynamic diameter (PM10) during each trimester, 0-6 months, 7-12 months (1990-1993), and up to age 15 years (1991-2008) were examined in relation to FEV1% predicted and FVC% predicted at ages 8 (n = 5,276) and 15 (n = 3,446) years using linear regression models adjusted for potential confounders. A profile regression model was used to identify sensitive time periods. Measurements and Main Results: We did not find clear evidence of a sensitive exposure period for PM10 from road traffic. At age 8 years, 1 mg/m(3) higher exposure during the first trimester was associated with lower FEV1% predicted ( 20.826; 95% confidence interval [CI], 21.357 to 20.296) and FVC% predicted (20.817; 95% CI, 21.357 to 20.276), but similar associations were seen for exposures for other trimesters, 0-6 months, 7-12 months, and 0-7 years. Associations were stronger among boys, as well as children whose mother had a lower education level or smoked during pregnancy. For PM10 from all sources, the third trimester was associated with lower FVC% predicted (21.312; 95% CI, 22.100 to 20.525). At age 15 years, no adverse associations with lung function were seen. Conclusions: Exposure to road-traffic PM10 during pregnancy may result in small but significant reductions in lung function at age 8 years.
引用
收藏
页码:112 / 123
页数:12
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