Helminth Therapy for Immune-Mediated Inflammatory Diseases: Current and Future Perspectives

被引：28

作者：

Shi, Wenjie ^{[1
]}

Xu, Ning ^{[1
]}

Wang, Xuelin ^{[1
]}

Vallee, Isabelle ^{[2
]}

Liu, Mingyuan ^{[1
]}

Liu, Xiaolei ^{[1
]}

机构：

[1] Jilin Univ, Coll Vet Med, Inst Zoonosis, Key Lab Zoonosis Res,Minist Educ, Changchun 130062, Peoples R China

[2] Ecole Natl Vet Alfort, Lab Sante Anim, INRAE, UMR BIPAR,Anses, Maisons Alfort, France

来源：

JOURNAL OF INFLAMMATION RESEARCH | 2022年 / 15卷

基金：

中国博士后科学基金; 中国国家自然科学基金;

关键词：

inflammatory bowel disease; allergic asthma; immunoregulation; IMIDs; helminth therapy; helminth-derived molecules; ALLERGIC AIRWAY INFLAMMATION; CD8(+) T-CELLS; BOWEL-DISEASE; DENDRITIC CELLS; ALTERNATIVE ACTIVATION; EGG ANTIGENS; RESPONSES; INFECTION; ASTHMA; CROHNS;

D O I：

10.2147/JIR.S348079

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Inflammatory bowel disease and allergic asthma, as typical immune-mediated inflammatory diseases (IMIDs), are associated with immune imbalance caused by complex interactions among environmental, genetic and bacterial factors. The changing immune imbalance of IMIDs not only causes serious pathological damages but also increases the difficulty of treatment. Helminths or helminth-derived molecules have been increasingly employed to treat IMIDs due to their immunoregulatory ability. Since helminth infection is not an appropriate treatment direction due to the complex immunoregulation and safety concerns, one of the new therapies is to harness the immunoregulation induced by the identified helminth-derived molecules using immune indexes as a guide. This review discusses the pathogenesis of inflammatory bowel disease and allergic asthma, and summarizes the therapeutic effect of helminths and the immunoregulatory mechanisms induced by helminth-derived molecules proposing therapeutic regimens.

引用

页码：475 / 491

页数：17

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