Local anesthetics and their adjuncts

被引：19
作者：
Mazoit, Jean-Xavier [1 ,2 ]
机构：
[1] Univ Paris Sud, INSERM, UMR788, Fac Med,Lab Anesthesie, F-94276 Le Kremlin Bicetre, France
[2] Hop Univ Paris Sud, AP HP, Dept Anesthesie Reanimat, Le Kremlin Bicetre, France
来源：
PEDIATRIC ANESTHESIA | 2012年 / 22卷 / 01期
关键词：
local anesthetics; pharmacology; regional anesthesia; CONTINUOUS EPIDURAL INFUSION; CEREBROSPINAL-FLUID CIRCULATION; INDUCED SYSTEMIC TOXICITY; ISOLATED RABBIT HEART; CAUDAL ANESTHESIA; PLASMA-CONCENTRATIONS; SUCCESSFUL RESUSCITATION; SODIUM-CHANNELS; POSTOPERATIVE ANALGESIA; INTRAVENOUS LIDOCAINE;
D O I：
10.1111/j.1460-9592.2011.03692.x
中图分类号：
R614 [麻醉学];
学科分类号：
100217 ;
摘要：
Local anesthetics (LA) block propagation of impulses along nerve fibers by inactivation of voltage-gated sodium channels, which initiate action potentials (1). They act on the cytosolic side of phospholipid membranes. Two main chemical compounds are used, amino esters and amino amides. Amino esters are degraded by pseudocholinesterases in plasma. Amino amides are metabolized exclusively by the liver. Only amide LAs will be considered in this article.
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页码：31 / 38
页数：8
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