Report of a consensus meeting on focal low dose rate brachytherapy for prostate cancer

被引：78

作者：

Langley, Stephen ^{[1
]}

Ahmed, Hashim U. ^{[2
]}

Al-Qaisieh, Bashar ^{[3
]}

Bostwick, David

Dickinson, Louise ^{[2
]}

Gomez Veiga, Francisco ^{[4
]}

Grimm, Peter ^{[5
]}

Machtens, Stefan ^{[6
]}

Guedea, Ferran ^{[7
]}

Emberton, Mark ^{[2
]}

机构：

[1] Royal Surrey Cty Hosp NHS Fdn Trust, Dept Urol, Guildford GU2 7XX, Surrey, England

[2] UCL, Div Surg & Intervent Sci, London WC1E 6BT, England

[3] St Jamess Inst Oncol, Dept Med Phys, Leeds, W Yorkshire, England

[4] Complejo Hosp Univ, Dept Urol, La Coruna, Spain

[5] Prostate Canc Treatment Ctr Seattle, Seattle, WA USA

[6] Marien Krankenhaus, Dept Urol, Bergisch Gladbach, Germany

[7] Catalan Inst Oncol, Dept Radiat Oncol, Barcelona, Spain

来源：

BJU INTERNATIONAL | 2012年 / 109卷

关键词：

prostate cancer; brachytherapy; focal therapy; patient selection; outcome; INTENSITY FOCUSED ULTRASOUND; RADICAL PROSTATECTOMY; INDEX LESION; BIOPSY; THERAPY; TUMOR; IMPACT; CS-131; ULTRASONOGRAPHY; RECOMMENDATIONS;

D O I：

10.1111/j.1464-410X.2011.10825.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Low dose rate prostate brachytherapy is an effective treatment for localized prostate cancer. Recently, it has been considered for use in a focused manner whereby treatment is targeted only to areas of prostate cancer. The objective of focal brachytherapy is to provide effective cancer control for low-risk disease but with reduced genitourinary and rectal side-effects in a cost-effective way. We report on the outputs of a consensus meeting of international experts in brachytherapy and focal therapy convened to consider the feasibility and potential development of focal brachytherapy. A number of factors were considered for focal brachytherapy including optimal patient selection, disease characterization and localization, treatment protocols and outcome measures. The consensus meeting also addressed the design of a clinical trial that would assess the oncological outcomes and side-effect profiles resulting from focal brachytherapy.

引用

页码：7 / 16

页数：10

共 56 条

[1] FOCAL SALVAGE THERAPY COMPARED TO WHOLE-GLAND SALVAGE: A FEASIBILITY STUDY [J].

Ahmed, H. U. ;

Cathcart, P. ;

McCartan, N. ;

Kirkham, A. ;

Allen, C. ;

Freeman, A. ;

Emberton, M. .

EUROPEAN UROLOGY SUPPLEMENTS, 2011, 10 (02) :92-93

[2] Focal Therapy for Localized Prostate Cancer: A Phase I/II Trial [J].

Ahmed, H. U. ;

Freeman, A. ;

Kirkham, A. ;

Sahu, M. ;

Scott, R. ;

Allen, C. ;

Van der Meulen, J. ;

Emberton, M. .

JOURNAL OF UROLOGY, 2011, 185 (04) :1246-1254

[3] Is it time to consider a role for MRI before prostate biopsy? [J].

Ahmed, Hashim U. ;

Kirkham, Alex ;

Arya, Manit ;

Illing, Rowland ;

Freeman, Alex ;

Allen, Clare ;

Emberton, Mark .

NATURE REVIEWS CLINICAL ONCOLOGY, 2009, 6 (04) :197-206

[4] Rectal fistulae after salvage high-intensity focused ultrasound for recurrent prostate cancer after combined brachytherapy and external beam radiotherapy [J].

Ahmed, Hashim U. ;

Ishaq, Ayesha ;

Zacharakis, Evangelos ;

Shaw, Greg ;

Illing, Rowland ;

Allen, Clare ;

Kirkham, Alex ;

Emberton, Mark .

BJU INTERNATIONAL, 2009, 103 (03) :321-323

[5] Characterizing Clinically Significant Prostate Cancer Using Template Prostate Mapping Biopsy [J].

Ahmed, Hashim Uddin ;

Hu, Yipeng ;

Carter, Tim ;

Arumainayagam, Nimalan ;

Lecornet, Emilie ;

Freeman, Alex ;

Hawkes, David ;

Barratt, Dean C. ;

Emberton, Mark .

JOURNAL OF UROLOGY, 2011, 186 (02) :458-464

[6] The Index Lesion and the Origin of Prostate Cancer [J].

Ahmed, Hashim Uddin .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (17) :1704-1706

[7]

Ahmed HU, 2011, CANCER IN PRESS

[8] Heterogeneity of gleason grade in multifocal adenocarcinorna of the prostate [J].

Arora, R ;

Koch, MO ;

Eble, JN ;

Ulbright, TM ;

Li, L ;

Cheng, L .

CANCER, 2004, 100 (11) :2362-2366

[9] A NEGATIVE MULTI-PARAMETRIC MRI CAN RULE OUT UP TO 97% OF CLINICALLY SIGNIFICANT PROSTATE CANCER [J].

Arumainayagam, N. ;

Ahmed, H. U. ;

Moore, C. M. ;

Freeman, A. ;

Sohaib, A. ;

Kirkham, A. ;

Allen, C. ;

Emberton, M. .

EUROPEAN UROLOGY SUPPLEMENTS, 2011, 10 (02) :66-67

[10] Accuracy of multiparametric magnetic resonance imaging in detecting recurrent prostate cancer after radiotherapy [J].

Arumainayagam, Nimalan ;

Kumaar, Senthil ;

Ahmed, Hashim U. ;

Moore, Caroline M. ;

Payne, Heather ;

Freeman, Alex ;

Allen, Clare ;

Kirkham, Alex ;

Emberton, Mark .

BJU INTERNATIONAL, 2010, 106 (07) :991-997

← 1 2 3 4 5 6 →