Effects of aqueous extracts from Quercus ilex L. root bark, Punica granatum L. fruit peel and Artemisia herba-alba asso leaves on ethanol-induced gastric damage in rats

被引：0

作者：

Gharzouli, K ^{[1
]}

Khennouf, S ^{[1
]}

Amira, S ^{[1
]}

Gharzouli, A ^{[1
]}

机构：

[1] Univ Ferhat Abbas, Inst Biol, Setif 19000, Algeria

来源：

PHYTOTHERAPY RESEARCH | 1999年 / 13卷 / 01期

关键词：

Artemisia herba-alba; Punica granatum; Quercus ilex; experimental gastric ulcer; polyphenols; gastric secretion;

D O I：

10.1002/(SICI)1099-1573(199902)13:1<42::AID-PTR383>3.0.CO;2-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The gastroprotective effect of tannic acid and the aqueous extract of Quercus ilex L. root bark, Punica granatum L, fruit peel and Artemisia herba-alba Asso leaves was investigated in the rat against ethanol-induced damage. Tannic acid, Q. ilex and P. granatum extracts gave 100% precipitation of ovine haemoglobin in vitro, whereas A. herba-alba extract was devoid of any protein-binding property. Oral administration of these plant extracts or tannic acid induced a significant decrease in gastric lesions (47.7%-76%), The observed protection was more pronounced when the test solution was given at the same time with ethanol, except for Q. ilex extract. The acid content of the stomach was significantly increased by P. granatum (368%) and A. herba-alba (251%) extracts prepared in ethanol, It is suggested that monomeric and polymeric polyphenols can strengthen the gastric mucosal barrier. (C) 1999 John Wiley & Sons, Ltd.

引用

页码：42 / 45

页数：4

共 27 条

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