Putting the DNA back into DNA methylation

被引:22
作者
Bird, Adrian [1 ]
机构
[1] Univ Edinburgh, Wellcome Trust Ctr Cell Biol, Edinburgh, Midlothian, Scotland
关键词
CPG ISLAND; TRANSCRIPTION;
D O I
10.1038/ng.987
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
The origin of DNA methylation patterns has been a mystery for many years. A new study identifies the DNA sequence itself as a key determinant and focuses attention on the role of transcription factors.
引用
收藏
页码:1050 / 1051
页数:3
相关论文
共 9 条
[1]   SP1 ELEMENTS PROTECT A CPG ISLAND FROM DE-NOVO METHYLATION [J].
BRANDEIS, M ;
FRANK, D ;
KESHET, I ;
SIEGFRIED, Z ;
MENDELSOHN, M ;
NEMES, A ;
TEMPER, V ;
RAZIN, A ;
CEDAR, H .
NATURE, 1994, 371 (6496) :435-438
[2]   Myc represses transcription through recruitment of DNA methyltransferase corepressor [J].
Brenner, C ;
Deplus, R ;
Didelot, C ;
Loriot, A ;
Viré, E ;
De Smet, C ;
Gutierrez, A ;
Danovi, D ;
Bernard, D ;
Boon, T ;
Pelicci, PG ;
Amati, B ;
Kouzarides, T ;
de Launoit, Y ;
Di Croce, L ;
Fuks, F .
EMBO JOURNAL, 2005, 24 (02) :336-346
[3]   CpG islands and the regulation of transcription [J].
Deaton, Aimee M. ;
Bird, Adrian .
GENES & DEVELOPMENT, 2011, 25 (10) :1010-1022
[4]   Widespread transcription at neuronal activity-regulated enhancers [J].
Kim, Tae-Kyung ;
Hemberg, Martin ;
Gray, Jesse M. ;
Costa, Allen M. ;
Bear, Daniel M. ;
Wu, Jing ;
Harmin, David A. ;
Laptewicz, Mike ;
Barbara-Haley, Kellie ;
Kuersten, Scott ;
Markenscoff-Papadimitriou, Eirene ;
Kuhl, Dietmar ;
Bito, Haruhiko ;
Worley, Paul F. ;
Kreiman, Gabriel ;
Greenberg, Michael E. .
NATURE, 2010, 465 (7295) :182-U65
[5]   Identification of genetic elements that autonomously determine DNA methylation states [J].
Lienert, Florian ;
Wirbelauer, Christiane ;
Som, Indrani ;
Dean, Ann ;
Mohn, Fabio ;
Schuebeler, Dirk .
NATURE GENETICS, 2011, 43 (11) :1091-U78
[6]   SP1 SITES IN THE MOUSE APRT GENE PROMOTER ARE REQUIRED TO PREVENT METHYLATION OF THE CPG ISLAND [J].
MACLEOD, D ;
CHARLTON, J ;
MULLINS, J ;
BIRD, AP .
GENES & DEVELOPMENT, 1994, 8 (19) :2282-2292
[7]   Regulating RNA polymerase pausing and transcription elongation in embryonic stem cells [J].
Min, Irene M. ;
Waterfall, Joshua J. ;
Core, Leighton J. ;
Munroe, Robert J. ;
Schimenti, John ;
Lis, John T. .
GENES & DEVELOPMENT, 2011, 25 (07) :742-754
[8]   Demystifying DNA Demethylation [J].
Nabel, Christopher S. ;
Kohli, Rahul M. .
SCIENCE, 2011, 333 (6047) :1229-1230
[9]   Insulators: many functions, many mechanisms [J].
West, AG ;
Gaszner, M ;
Felsenfeld, G .
GENES & DEVELOPMENT, 2002, 16 (03) :271-288