Natural history of sensitization, symptoms and occupational diseases in apprentices exposed to laboratory animals

被引:83
作者
Gautrin, D
Ghezzo, H
Infante-Rivard, C
Malo, JL
机构
[1] Hop Sacre Coeur, Dept Chest Med, Montreal, PQ H4J 1C5, Canada
[2] McGill Univ, Joint Dept Epidemiol & Biostat & Occupat Hlth, Montreal, PQ H3A 2T5, Canada
关键词
asthma; immunological sensitization; occupational asthma;
D O I
10.1183/09031936.01.17509040
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The natural history of the development of sensitization and disease due to high-molecular-weight allergens is not well characterized. This study describes the timecourse of the incidence of work-related symptoms, skin reactivity and occupational rhinoconjunctivitis (RC) and asthma (OA); and assesses the predictive value of skin testing and RC symptoms in apprentices exposed to laboratory animals, in a 3-4-yr programme. Four-hundred and seventeen apprentices at five institutions were assessed prospectively with questionnaire, skin-testing with animal-derived allergens, spirometry and airway responsiveness (n = 373). Depending on the school, students were seen 8 (n = 136), 20 (n = 345), 32 (n = 355) and 44 (n = 98) months after starting the programme. At all visits, the incidence was greater for work-related RC symptoms followed in order by skin reactivity, occupational RC, and, almost equally, OA and work-related respiratory symptoms. The incidence-density figures were comparable for each followup period and for most indices up to 32 months after entry into the study and then tended to decrease. The positive predictive values (PPVs) of skin reactivity to work-related allergens for the development of work-related RC and respiratory symptoms were 30% and 9.0%, respectively, while the PPVs of work-related RC for the development of OA was 11.4%. Sensitization, symptoms and diseases occur maximally in the first 2-3 yrs after starting exposure to laboratory animals. Skin reactivity to work-related allergens and rhinoconjuctivitis symptoms have low positive predictive values.
引用
收藏
页码:904 / 908
页数:5
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