Recent developments in cannabinoid ligands

被引：42
作者：
Padgett, LW [1 ]
机构：
[1] Clemson Univ, Howard L Hunter Chem Lab, Clemson, SC 29634 USA
来源：
LIFE SCIENCES | 2005年 / 77卷 / 14期
关键词：
cannabinoid; structure-activity relationship; pyrazole; aminoalkylindole;
D O I：
10.1016/j.lfs.2005.05.020
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Over the past 40 years, much research has been carried out directed toward the characterization of the cannabinergic system. With the identification of two G-protein coupled receptors and the endogenous ligand, anandamide, pharmacological targets have expanded to encompass hydrolase and transport proteins as well as novel classes of cannabinoid ligands. Those ligands that demonstrate high affinity for the receptors and good biological efficacy are tied together through lipophilic regions repeatedly demonstrated necessary for activity. This review presents recent developments in the structure-activity relationships of several classes of cannabinoid ligands. (c) 2005 Elsevier Inc. All rights reserved.
引用
收藏
页码：1767 / 1798
页数：32
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