Complete response to talazoparib in patient with pancreatic adenocarcinoma harboring somatic PALB2 mutation: A case report and literature review

被引:1
|
作者
Kachmazov, Andrei [1 ]
Bolotina, Larisa [1 ]
Kornietskaya, Anna [1 ]
Kuznetsova, Olesya [2 ,3 ]
Ivanov, Maxim [3 ]
Fedenko, Alexander [1 ]
机构
[1] Minist Hlth Russian Federat, P Hertsen Moscow Oncol Clin Res Inst, Branch Natl Med Res Radiol Ctr, Moscow, Russia
[2] NN Blokhin Natl Med Res Ctr Oncol Minist Hlth Russ, Fed State Budgetary Inst, Moscow, Russia
[3] Atlas Oncodiagnost LLC, RnD Dept, Moscow, Russia
来源
FRONTIERS IN ONCOLOGY | 2022年 / 12卷
关键词
pancreatic cancer; PDAC; talazoparib; PARP inhibitors; PARPi; PALB2; molecular profiling; precision oncology; CANCER; GEMCITABINE; TRIAL;
D O I
10.3389/fonc.2022.953908
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PARP inhibitors have recently emerged as a maintenance treatment option for metastatic pancreatic cancer patients with germline BRCA mutations. However, the possibility of PARP-inhibitor use as a standalone-targeted therapy for patients with various homologous repair pathway alterations remains mostly undetermined. Here we report a clinical case of a 56-year-old woman with pancreatic ductal adenocarcinoma harboring a somatic PALB2 mutation. Following disease progression after 10 cycles of FOLFIRINOX chemotherapy and two cycles of second-line gemcitabine, she was switched to talazoparib and achieved a complete clinical response after 25 months of treatment. The patient remains alive without clinical or radiological signs of disease progression three years after the start of talazoparib with no targeted therapy-related toxicities. This case highlights the role of broad molecular profiling as a window of opportunity to achieve a durable response for selected pancreatic cancer patients while pinpointing our gaps in understanding the whole picture of management of these patients since a new puzzle element represented by PARP inhibitors was introduced to clinical practice.
引用
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页数:6
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