Steroid hormone measurements from different types of assays in relation to body mass index and breast cancer risk in postmenopausal women: Reanalysis of eighteen prospective studies

被引：80

作者：

Key, T. J. ^{[1
]}

Appleby, P. N. ^{[1
]}

Reeves, G. K. ^{[1
]}

Travis, R. C. ^{[1
]}

Brinton, L. A. ^{[2
]}

Dallal, C. M. ^{[3
]}

Helzlsouer, K. J. ^{[4
]}

Hoffman-Bolton, J. ^{[5
]}

Visvanathan, K. ^{[5
]}

Dorgan, J. F. ^{[6
]}

Falk, R. T. ^{[7
]}

Gapstur, S. M. ^{[8
]}

Gaudet, M. M. ^{[8
]}

Kaaks, R. ^{[9
]}

Riboli, E. ^{[10
]}

Rinaldi, S. ^{[11
]}

Key, T. ^{[1
]}

Manjer, J. ^{[12
]}

Hallmans, G. ^{[13
]}

Giles, G. G. ^{[14
]}

Le Marchand, L. ^{[15
]}

Kolonel, L. N. ^{[15
]}

Henderson, B. E. ^{[16
]}

Tworoger, S. S. ^{[17
,18
,19
]}

Hankinson, S. E. ^{[17
,18
,19
,20
]}

Zeleniuch-Jacquotte, A. ^{[21
]}

Koenig, K. ^{[21
]}

Krogh, V. ^{[22
]}

Sieri, S. ^{[22
]}

Muti, P. ^{[23
]}

Ziegler, R. G. ^{[24
]}

Schairer, C. ^{[24
]}

Fuhrman, B. J. ^{[25
]}

Barrett-Connor, E. ^{[26
]}

Laughlin, G. A. ^{[26
]}

Grant, E. J. ^{[27
]}

Cologne, J. ^{[28
]}

Ohishi, W. ^{[29
]}

Hida, A. ^{[29
]}

Cauley, J. A. ^{[30
]}

Fourkala, E.-O. ^{[31
]}

Rohan, T. E. ^{[32
]}

Strickler, H. D. ^{[32
]}

Gunter, M. J. ^{[10
]}

机构：

[1] Univ Oxford, Nuffield Dept Populat Hlth, Canc Epidemiol Unit, Oxford OX3 7LF, England

[2] Natl Canc Inst, Hormonal & Reproduct Epidemiol Branch, Bethesda, MD USA

[3] Univ Maryland, Sch Publ Hlth, Dept Epidemiol & Biostat, College Pk, MD USA

[4] Mercy Med Ctr, Prevent & Res Ctr, Baltimore, MD USA

[5] Johns Hopkins Univ, George W Comstock Ctr Public Hlth Res & Prevent, Hagerstown, MD USA

[6] Univ Maryland, Sch Med, Baltimore, MD USA

[7] Natl Canc Inst, Div Canc Epidemiol & Genet, Hormonal & Reproduct Epidemiol Branch, Bethesda, MD USA

[8] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA USA

[9] DKFZ, Heidelberg, Germany

[10] Imperial Coll, Sch Publ Hlth, London, England

[11] Int Agcy Res Canc, Lyon, France

[12] Malmo Univ Hosp, Dept Surg, Malmo, Sweden

[13] Umea Univ Hosp, Dept Clin Med & Publ Hlth, Umea, Sweden

[14] Canc Council Victoria, Canc Epidemiol Ctr, Melbourne, Vic, Australia

[15] Univ Hawaii Canc Ctr, Epidemiol Program, Honolulu, HI USA

[16] Univ So Calif, Los Angeles, CA USA

[17] Brigham & Womens Hosp, Dept Med, Channing Div Network Med, Boston, MA USA

[18] Harvard Med Sch, Boston, MA USA

[19] Harvard Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[20] Univ Massachusetts, Div Biostat & Epidemiol, Amherst, MA USA

[21] NYU, Sch Med, Dept Environm Med, New York, NY USA

[22] Fdn IRCCS Ist Nazl Tumori, Milan, Italy

[23] McMaster Univ, Dept Oncol, Hamilton, ON, Canada

[24] Natl Canc Inst, Div Canc Epidemiol & Genet, Epidemiol & Biostat Program, Bethesda, MD USA

[25] Univ Arkansas Med Sci, Fay W Boozman Coll Publ Hlth, Dept Epidemiol, Little Rock, AR USA

[26] Univ Calif San Diego, Dept Family & Prevent Med, Div Epidemiol, San Diego, CA USA

[27] Radiat Effects Res Fdn, Dept Epidemiol, Hiroshima, Nagasaki, Japan

[28] Radiat Effects Res Fdn, Dept Stat, Hiroshima, Nagasaki, Japan

[29] Radiat Effects Res Fdn, Dept Clin Studies, Hiroshima, Nagasaki, Japan

[30] Univ Pittsburgh, Dept Epidemiol, Pittsburgh, PA USA

[31] UCL, Inst Womens Hlth, Womens Canc, London, England

[32] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY USA

来源：

STEROIDS | 2015年 / 99卷

关键词：

Breast cancer; Estradiol; Body mass index; Extraction immunoassay; Direct immunoassay; Mass spectrometry; ESTROGEN METABOLISM; SERUM ESTRADIOL; TESTOSTERONE; ANDROGEN; SHBG;

D O I：

10.1016/j.steroids.2014.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Epidemiological studies have examined breast cancer risk in relation to sex hormone concentrations measured by different methods: "extraction" immunoassays (with prior purification by organic solvent extraction, with or without column chromatography), "direct" immunoassays (no prior extraction or column chromatography), and more recently with mass spectrometry-based assays. We describe the associations of estradiol, estrone and testosterone with both body mass index and breast cancer risk in postmenopausal women according to assay method, using data from a collaborative pooled analysis of 18 prospective studies. In general, hormone concentrations were highest in studies that used direct assays and lowest in studies that used mass spectrometry-based assays. Estradiol and estrone were strongly positively associated with body mass index, regardless of the assay method; testosterone was positively associated with body mass index for direct assays, but less clearly for extraction assays, and there were few data for mass spectrometry assays. The correlations of estradiol with body mass index, estrone and testosterone were lower for direct assays than for extraction and mass spectrometry assays, suggesting that the estimates from the direct assays were less precise. For breast cancer risk, all three hormones were strongly positively associated with risk regardless of assay method (except for testosterone by mass spectrometry where there were few data), with no statistically significant differences in the trends, but differences may emerge as new data accumulate. Future epidemiological and clinical research studies should continue to use the most accurate assays that are feasible within the design characteristics of each study. (C) 2014 The Authors. Published by Elsevier Inc.

引用

页码：49 / 55

页数：7

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