Fibrosis of the lung and other tissues: New concepts in pathogenesis and treatment

被引：286

作者：

Sime, PJ ^{[1
]}

O'Reilly, KMA ^{[1
]}

机构：

[1] Univ Rochester, Sch Med, Div Pulm & Crit Care Med, Rochester, NY 14642 USA

来源：

CLINICAL IMMUNOLOGY | 2001年 / 99卷 / 03期

关键词：

fibrosis; TGF-beta; CD40; ligand; Th1; cytokines; Th2;

D O I：

10.1006/clim.2001.5008

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Tissue fibrosis can lead to significant organ dysfunction and resulting patient morbidity and mortality. Unfortunately, the therapeutic repertoire is currently limited, nonspecific, and largely ineffective. While the pathogenesis is incompletely understood, evidence is accumulating that immune and cytokine mediated mechanisms are critical. In this review, data will be provided to support the role of Type 2 cytokines in the pathogenesis of fibrosis. The importance of the role of the pro-fibrogenic cytokine TGF-beta and CD40-CD40 ligand mediated fibroblast activation will also be evaluated. Finally, novel therapeutic options based on inhibiting these pathways will be described. (C) 2001 Academic Press.

引用

页码：308 / 319

页数：12

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