Solvation and enthalpy coefficients of interaction of carboxylic acid amides with 1,2-diols in water

The enthalpies of solution of formamides, acetamides, and propionamides with various extents of N-substitution in aqueous solutions of propylene alycol and 1,2-butanediol (concentration less than or equal to 4 mol kg(-1)) at 298.15 K were measured. The enthalpies of transfer of the amides from water to mixed aqueous-organic solvents were determined and discussed in combination with data on the enthalpies of transfer of amides from water to aqueous ethylene glycol solutions. The enthalpy coefficients of pair interactions of amides with 1,2-diols in water were calculated and used for evaluating the group components on the basis of the principle of group additivity of contributions. As the hydrophobic properties of polyfunctional nonelectrolytes are enhanced, the coefficients increase, which is due to the growth of the hydrophobic component of the interaction.