Fluorimetric determination of gatifloxacin in aqueous, pure and pharmaceutical formulations

被引：10

作者：

Razek, Taha M. A. ^{[1
]}

El-Baqary, Ramzia I. ^{[2
]}

Ramadan, Ahmed E. ^{[1
]}

机构：

[1] Ain Shams Univ, Inst Environm Studies & Res, Environm Basic Sci Dept, Cairo, Egypt

[2] Cairo Univ, Dept Chem, Fac Pharm, Cairo, Egypt

来源：

ANALYTICAL LETTERS | 2008年 / 41卷 / 03期

关键词：

gatifloxacin determination; fluorimetry; pharmaceutical formulations;

D O I：

10.1080/00032710701746816

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A spectrofluorimetric method was developed for the determination of gatifloxacin. The emission peak for gatifloxacin was recorded at 495nm upon excitation at 291nm. The fluorescence process was pH dependent. The dynamic range for the method was 16-80ng ml(-1)with detection limit of 3.97ng ml(-1). A linear relationship between the fluorescence intensity and the concentration of gatifloxacin solution was obtained with r(2) of 0.9968. The method has successfully applied to the determination of gatifloxacin in pure, authentic and aqueous samples.

引用

页码：417 / 423

页数：7

共 9 条

[1]

Hairui L, 2002, J CHROMATOGR B, V772, P53

[2]

LAURA JV, 2002, ANTIMICROB AGENTS CH, V46, P813

[3] Simultaneous determination of levofloxacin, gatifloxacin and moxifloxacin in serum by liquid chromatography with column switching [J].

Nguyen, HA ;

Grellet, J ;

Ba, BB ;

Quentin, C ;

Saux, MC .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2004, 810 (01) :77-83

[4] Spectrofluorimetric and micelle-enhanced spectrofluorimetric determination of gatifloxacin in human urine and serum [J].

Ocaña, JA ;

Barragán, FJ ;

Callejón, M .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2005, 37 (02) :327-332

[5] Determination of gatifloxacin in human serum and urine by high-performance liquid chromatography with ultraviolet detection [J].

Overholser, BR ;

Kays, MB ;

Sowinski, KM .

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2003, 798 (01) :167-173

[6] Quantitative determination of gatifloxacin, levofloxacin, lomefloxacin and pefloxacin fluoroquinolonic antibiotics in pharmaceutical preparations by high-performance liquid chromatography [J].

Santoro, MIRM ;

Kassab, NM ;

Singh, AK ;

Kedor-Hackmam, ERM .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2006, 40 (01) :179-184

[7]

Sweetman SC, 2002, MARTINDALE

[8]

VENUGOPAL K, 2005, NEW SIMPLE VALIDATED, V60, P906

[9]

ZHU M, 2003, YAOWU FENXI ZAZHI, V23, P53

← 1 →