n-3 Polyunsaturated fatty acids and mast cell activation

被引：12

作者：

Wang, Xiaofeng ^{[1
]}

Kulka, Marianna ^{[2
,3
]}

机构：

[1] Univ Alberta, Dept Agr Food & Nutr Sci, Edmonton, AB, Canada

[2] Univ Alberta, Dept Med Microbiol & Immunol, Edmonton, AB, Canada

[3] Natl Res Council Canada, Natl Inst Nanotechnol, Edmonton, AB T6G 2M9, Canada

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2015年 / 97卷 / 05期

关键词：

EPA; DHA; Fc epsilon RI; lipid rafts; eicosanoid; FC-EPSILON-RI; VASCULAR SMOOTH-MUSCLE; NERVE GROWTH-FACTOR; RECEPTOR CROSS-LINKING; LPS-INDUCED PRODUCTION; AFFINITY IGE RECEPTOR; GAMMA-LINOLENIC ACID; MAJOR BASIC-PROTEIN; EICOSAPENTAENOIC ACID; AIRWAY HYPERRESPONSIVENESS;

D O I：

10.1189/jlb.2RU0814-388R

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Mast cells are known to play a vital role in the development of inflammation in allergic responses. Recent studies have indicated that mast cell activation could be modulated by n-3 PUFAs, which have a wide range of well-documented health benefits. In our review, we summarize the recent findings and potential mechanisms of the effect of n-3 PUFAs on mast cell activation. This knowledge could provide new strategies for the development of therapeutic interventions for diseases mediated by mast cells.

引用

页码：859 / 871

页数：13

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