Amino Acid-Directed Strategy for Inducing the Marine-Derived Fungus Scedosporium apiospermum F41-1 to Maximize Alkaloid Diversity

被引：65

作者：

Huang, Li-Hong ^{[1
,6
]}

Xu, Meng-Yang ^{[1
]}

Li, Hou-Jin ^{[2
]}

Li, Jin-Qian ^{[3
,4
]}

Chen, Yan-Xiu ^{[1
,6
]}

Ma, Wen-Zhe ^{[5
]}

Li, Yi-Ping ^{[3
,4
]}

Xu, Jun ^{[1
]}

Yang, De-Po ^{[1
,6
]}

Lan, Wen-Jian ^{[1
,6
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Sch Chem, Guangzhou 510006, Guangdong, Peoples R China

[3] Sun Yat Sen Univ, Inst Human Virol, Guangzhou 510080, Guangdong, Peoples R China

[4] Sun Yat Sen Univ, Zhongshan Sch Med, Guangzhou 510080, Guangdong, Peoples R China

[5] Macau Univ Sci & Technol, State Key Lab Qual Res Chinese Med, Macau Inst Appl Res Med & Hlth, Ave Wai Long, Taipa 519020, Macau, Peoples R China

[6] Guangdong Technol Res Ctr Adv Chinese Med, Guangzhou 510006, Guangdong, Peoples R China

来源：

ORGANIC LETTERS | 2017年 / 19卷 / 18期

关键词：

D O I：

10.1021/acs.orglett.7b02238

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

By feeding various amino acids to the marine fungus Scedosporium apiospermum F41-1, 22 diverse alkaloids, including 14 new compounds, were obtained. Scedapins A-E (1-5) possess a rare skeleton of a pyrazinoquinazolinedione and an imidazoindolone/indolone linked by a tetrahydrofuran ring. Scedapin C (3) is the first example of fumiquinazoline that contains an aminosulfonyl group. Their structures were determined by HRMS, NMR, ECD calculations and X-ray single-crystal diffraction analysis. The biosynthetic pathways of fumiquinazolines 1-18 were proposed. Scedapin C (3) and scequinadoline D (8) displayed significant antiviral activity against hepatitis C.

引用

页码：4888 / 4891

页数：4

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