The translocator protein (18 kDa) and its role in neuropsychiatric disorders

被引：23

作者：

Barichello, Tatiana ^{[1
,2
]}

Simoes, Lutiana R. ^{[2
]}

Collodel, Allan ^{[2
]}

Giridharan, Vijayasree V. ^{[1
]}

Dal-Pizzol, Felipe ^{[3
]}

Macedo, Danielle ^{[4
]}

Quevedo, Joao ^{[1
,5
,6
,7
]}

机构：

[1] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Translat Psychiat Program, Houston, TX USA

[2] Univ Southern Santa Catarina UNESC, Hlth Sci Unit, Grad Program Hlth Sci, Lab Expt Microbiol, Criciuma, SC, Brazil

[3] Univ Southern Santa Catarina UNESC, Hlth Sci Unit, Grad Program Hlth Sci, Lab Expt Pathophysiol, Criciuma, SC, Brazil

[4] Univ Fed Ceara, Fac Med, Dept Physiol & Pharmacol, Neuropharmacol Lab,Drug Res & Dev Ctr, Fortaleza Ufc, CE, Brazil

[5] Univ Southern Santa Catarina UNESC, Hlth Sci Unit, Grad Program Hlth Sci, Lab Neurosci, Criciuma, SC, Brazil

[6] Univ Texas Hlth Sci Ctr Houston UTHlth, McGovern Med Sch, Dept Psychiat & Behav Sci, Ctr Excellence Mood Disorders, Houston, TX USA

[7] Univ Texas MD Anderson Canc Ctr UTHlth, Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX USA

来源：

NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS | 2017年 / 83卷

关键词：

TSPO; TSPO ligands; Neuroinflammation; Neuropsychiatric disorders; PERIPHERAL BENZODIAZEPINE-RECEPTOR; IMAGING MICROGLIAL ACTIVATION; POSITRON-EMISSION-TOMOGRAPHY; ADULT SEPARATION ANXIETY; DEPENDENT ANION CHANNEL; CELL-TARGETED DELETION; NECROSIS-FACTOR-ALPHA; H-3 DIAZEPAM BINDING; IN-VIVO DETECTION; MOUSE MODEL;

D O I：

10.1016/j.neubiorev.2017.10.010

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Translocator protein (TSPO) is an 18 kDa translocator membrane protein expressed in the outer mitochondrial membrane of steroid-synthesizing cells in the central and peripheral nervous systems. TSPO is involved in cellular functions, including the regulation of cell proliferation, transport of cholesterol to the inner mitochondrial membranes of glial cells, regulation of mitochondrial quality control, and haem synthesis. In the brain, TSPO has been extensively used as a biomarker of injury and inflammation. Indeed, TSPO was up regulated in several inflammatory and neurodegenerative diseases. In contrast, the expression of TSPO was decreased in peripheral blood from psychiatric patients. Since TSPO is involved in several mechanisms related to mitochondrial function and inflammatory alterations, therapeutic approaches focusing on the regulation of TSPO may provide a new avenue for the treatment of neuropsychiatric disorders. Based on the involvement of mitochondrial alterations in the neurobiology of neuropsychiatric disorders, this review will focus on the functions and physiological roles of TSPO and the potential of TSPO ligands as therapeutic strategies for the treatment of neuropsychiatric disorders.

引用

页码：183 / 199

页数：17

共 173 条

[1] Reductions in Platelet 18-kDa Translocator Protein Density Are Associated with Adult Separation Anxiety in Patients with Bipolar Disorder [J].