The Role of Exosomal Non-Coding RNAs in Colorectal Cancer Drug Resistance

被引：42

作者：

Lampropoulou, Dimitra Ioanna ^{[1
]}

Pliakou, Evangelia ^{[1
]}

Aravantinos, Gerasimos ^{[1
]}

Filippou, Dimitrios ^{[2
]}

Gazouli, Maria ^{[3
]}

机构：

[1] Gen Oncol Hosp Kifissia Agioi Anargiroi, Dept Med Oncol 2, Athens 14564, Greece

[2] Natl & Kapodistrian Univ Athens, Sch Med, Dept Anat & Surg Anat, Athens 11527, Greece

[3] Natl & Kapodistrian Univ Athens, Sch Med, Lab Biol, Athens 11527, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 03期

关键词：

extracellular vesicles; exosomes; non-coding RNAs; colorectal cancer; chemoresistance; drug resistance; BREAST-CANCER; EXTRACELLULAR VESICLES; INTERCELLULAR TRANSFER; SMALL MOLECULES; P-GLYCOPROTEIN; CELLS; DELIVERY; CHEMORESISTANCE; MICROVESICLES; EXPRESSION;

D O I：

10.3390/ijms23031473

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Colorectal cancer (CRC) is one of the most common types of cancer diagnosed worldwide with high morbidity; drug resistance is often responsible for treatment failure in CRC. Non-coding RNAs (ncRNAs) play distinct regulatory roles in tumorigenesis, cancer progression and chemoresistance. Methods: A literature search was conducted in PubMed database in order to sum up and discuss the role of exosomal ncRNAs (ex-ncRNAs) in CRC drug resistance/response and their possible mechanisms. Results: Thirty-six (36) original research articles were identified; these included exosome or extracellular vesicle (EV)-containing microRNAs (miRNAs), long non-coding RNAs (lncRNAs), circular RNAs (circRNAs) and small-interfering (siRNAs). No studies were found for piwi-interacting RNAs. Conclusions: Exosomal transfer of ncRNAs has been documented as a new mechanism of CRC drug resistance. Despite being in its infancy, it has emerged as a promising field for research in order to (i) discover novel biomarkers for therapy monitoring and/or (ii) reverse drug desensitization.

引用

页数：23

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