Prenatal Folate and Choline Levels and Brain and Cognitive Development in Children: A Critical Narrative Review

被引：38

作者：

Irvine, Nathalie ^{[1
]}

England-Mason, Gillian ^{[2
,3
]}

Field, Catherine J. ^{[4
]}

Dewey, Deborah ^{[2
,3
,5
,6
]}

Aghajafari, Fariba ^{[6
,7
]}

机构：

[1] Univ Calgary, Cumming Sch Med, OBrien Ctr Bachelor Hlth Sci, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

[2] Univ Calgary, Alberta Childrens Hosp, Owerko Ctr, Res Inst, 2500 Univ Dr NW, Calgary, AB T2N 1N4, Canada

[3] Alberta Childrens Prov Gen Hosp, Cumming Sch Med, Dept Pediat, 28 Oki Dr NW, Calgary, AB T3B 6A8, Canada

[4] Univ Alberta, Dept Agr Food & Nutr Sci, 4-126C Li Ka Shing Ctr Res,11203-87th Ave NW, Edmonton, AB T6G 2H5, Canada

[5] Univ Calgary, Cumming Sch Med, Hlth Res Innovat Ctr, Hotchkiss Brain Inst, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

[6] Univ Calgary, Cumming Sch Med, Dept Community Hlth Sci, 3D10,3280 Hosp Dr NW, Calgary, AB T2N 4Z6, Canada

[7] Univ Calgary, Cumming Sch Med, Dept Family Med, G012,3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada

来源：

NUTRIENTS | 2022年 / 14卷 / 02期

关键词：

pregnancy; choline; folate; children; neurodevelopment; brain development; cognitive development; NEURAL-TUBE DEFECTS; BLOOD-CELL FOLATE; FOLIC-ACID SUPPLEMENTATION; DIETARY CHOLINE; VITAMIN-B-12; CONCENTRATIONS; DOUBLE-BLIND; MATERNAL PLASMA; PREGNANT-WOMEN; DEFICIENCY; AVAILABILITY;

D O I：

10.3390/nu14020364

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Women's nutritional status during pregnancy can have long-term effects on children's brains and cognitive development. Folate and choline are methyl-donor nutrients and are important for closure of the neural tube during fetal development. They have also been associated with brain and cognitive development in children. Animal studies have observed that prenatal folate and choline supplementation is associated with better cognitive outcomes in offspring and that these nutrients may have interactive effects on brain development. Although some human studies have reported associations between maternal folate and choline levels and child cognitive outcomes, results are not consistent, and no human studies have investigated the potential interactive effects of folate and choline. This lack of consistency could be due to differences in the methods used to assess folate and choline levels, the gestational trimester at which they were measured, and lack of consideration of potential confounding variables. This narrative review discusses and critically reviews current research examining the associations between maternal levels of folate and choline during pregnancy and brain and cognitive development in children. Directions for future research that will increase our understanding of the effects of these nutrients on children's neurodevelopment are discussed.

引用

页数：22