A streamlined synthesis for 2,3-dihydroxyterephthalamides

被引：20

作者：

Gramer, CJ

Raymond, KN ^{[1
]}

机构：

[1] Univ Calif Berkeley, Div Chem Sci, Lawrence Berkeley Natl Lab, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, Dept Chem, Berkeley, CA 94720 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 18期

关键词：

D O I：

10.1021/ol016253u

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] 2,3-Dihydroxyterephthalamides have been synthesized through a route that avoids the protection and deprotection of the phenol groups. The procedure allows for symmetric and unsymmetric amide linkages. This synthetic sequence significantly decreases the time and cost of preparation and increases the overall yield of this class of metal chelators.

引用

页码：2827 / 2830

页数：4

共 25 条

[1]

ANSCHUTZ R, 1894, CHEM BER, V27, P2751

[2]

COREY E J, 1977, Tetrahedron Letters, V45, P3923

[3]

COREY E J, 1977, Tetrahedron Letters, V45, P3919

[4] RATIONALLY DESIGNED, POTENT COMPETITIVE INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS [J].