Associations between observed concentrations of ethylene oxide in whole blood and smoking, exposure to environmental tobacco smoke, and cancers including breast cancer: data for US children, adolescents, and adults

For the first time, National Health and Nutrition Examination Survey released data on ethylene oxide (ETO) into public domain for US children aged 6-11 years, adolescents aged 12-19 years, and adults aged >= 20 years for 2013-2016. This study was undertaken to evaluate the associations between concentrations of ETO in whole blood and smoking, exposure to environmental tobacco smoke (ETS), and self-reported diagnosis of cancers including breast cancer. Both adolescent (29.6 vs. 49.6 pmol/g Hb, p < 0.01) and adult smokers (31.5 vs. 142.7 pmol/g Hb, p < 0.01) were found to have substantially higher adjusted levels of ethylene oxide than nonsmokers. Non-Hispanic blacks had higher levels of ethylene oxide than other race/ethnicities for children and adolescents. Non-Hispanic Asians had higher levels of ethylene oxide than other race/ethnicities for adults. Exposure to ETO measured by the number of smokers smoking inside the home (p < 0.01) and number of days smokers smoked inside the home (p = 0.03) during the prior week was found to be associated with elevated levels of ETO (p < 0.01) among US adults. Increased age was associated with elevated levels of ETO among adolescents (p = 0.02) and adults (p < 0.01) but the reverse was true for children (p = 0.04). For the general US population, levels of ETO were not found to be associated with cancers including breast cancer.