Catalytic asymmetric Michael reactions of acetaldehyde

被引：206

作者：

Garcia-Garcia, Patricia ^{[1
]}

Ladepeche, Arnaud ^{[1
]}

Halder, Rajkumar ^{[1
]}

List, Benjamin ^{[1
]}

机构：

[1] Max Planck Inst Kohlenforsch, D-45470 Mulheim, Germany

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 25期

关键词：

asymmetric catalysis; Michael addition; nitroolefins; organocatalysis; synthetic methods;

D O I：

10.1002/anie.200800847

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Acetaldehyde, now a big contender: A silyl prolinol derivative was found to catalyze the first Michael addition of acetaldehyde with both aromatic and aliphatic nitroolefins in excellent enantioselectivities (see scheme, TMS = trimethylsilyl). The utility of the reaction is illustrated in the synthesis of three current pharmaceuticals and in the synthesis of an enantiopure 3-monosubstituted pyrrolidine. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4719 / 4721

页数：3

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