CRM1-Dependent Trafficking of Retroviral Gag Proteins Revisited

被引：20

作者：

Baluyot, Mariju F. ^{[3
]}

Grosse, Sarah A. ^{[2
]}

Lyddon, Terri D. ^{[1
]}

Janaka, Sanath K. ^{[1
]}

Johnson, Marc C. ^{[1
]}

机构：

[1] Univ Missouri, Christopher S Bond Life Sci Ctr, Columbia, MO 65211 USA

[2] Rosalind Franklin Univ Med & Sci, Chicago, IL USA

[3] New York Med Coll, Valhalla, NY 10595 USA

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 08期

关键词：

ROUS-SARCOMA-VIRUS; NUCLEAR EXPORT; P10; DOMAIN; LOCALIZATION; RNA; MATRIX; ENTRY;

D O I：

10.1128/JVI.07199-11

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We analyzed the nuclear trafficking ability of Gag proteins from six retroviral genera. Contrary to a previous report, human immunodeficiency virus type 1 (HIV-1) Gag showed no propensity to cycle through the nucleus. The only Gag protein that displayed CRM1-dependent nuclear cycling was that of Rous sarcoma virus (RSV). Surprisingly, this cycling could be eliminated without compromising infectivity by replacing the RSV Gag N-terminal matrix (MA) domain with HIV MA.

引用

页码：4696 / 4700

页数：5

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