Novel PEGylated pH-sensitive polymeric hollow microspheres

被引：11

作者：

Bilalis, Panayiotis ^{[1
]}

Boukos, Nikos ^{[1
]}

Kordas, George ^{[1
]}

机构：

[1] NCSR Demokritos, Inst Mat Sci, GR-15310 Athens, Greece

来源：

MATERIALS LETTERS | 2012年 / 67卷 / 01期

基金：

欧洲研究理事会;

关键词：

PEG; pH-sensitive; PEGylated; Hollow microspheres; Polymer; PMAA; DISTILLATION-PRECIPITATION POLYMERIZATION; G-ETHYLENE GLYCOL); METHYL-ETHER; MONODISPERSE; NANOSPHERES; COPOLYMERS; RELEASE; PROTEIN;

D O I：

10.1016/j.matlet.2011.09.062

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Novel PEGylated pH-sensitive poly[methacrylic acid-co-poly(ethylene glycol) methyl ether methacrylate] [P(MAA-co-PEGMA)] hollow microspheres were synthesized by a two-stage distillation precipitation polymerization. PMAA@P(MAA-co-PEGMA) core shell microspheres were synthesized by the second-stage polymerization of MAA and PEGMA, using the N,N'-methylenebisacrylamide (MBAAm) as crosslinker in the presence of non-crosslinked PMAA microspheres. The cavity was formed by selective removal of PMAA core in ethanol. The resulted PEGylated hollow microspheres were characterized with Transmission Electron Microscopy (TEM), Scanning Electron Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FT-IR). The shrink and swelling behavior under different pH was studied by Dynamic Light Scattering (DLS). (C) 2011 Elsevier B.V. All rights reserved.

引用

页码：180 / 183

页数：4

共 16 条

[1] Synthesis of monodisperse poly(methacrylic acid) microspheres by distillation-precipitation polymerization [J].

Bai, Feng ;

Huang, Bo ;

Yang, Xinlin ;

Huang, Wenqiang .

EUROPEAN POLYMER JOURNAL, 2007, 43 (09) :3923-3932

[2] Chemisorbed poly(propylene sulphide)-based copolymers resist biomolecular interactions [J].

Bearinger, JP ;

Terrettaz, S ;

Michel, R ;

Tirelli, N ;

Vogel, H ;

Textor, M ;

Hubbell, JA .

NATURE MATERIALS, 2003, 2 (04) :259-264

[3] Water, solute and protein diffusion in physiologically responsive hydrogels of poly(methacrylic acid-g-ethylene glycol) [J].

Bell, CL ;

Peppas, NA .

BIOMATERIALS, 1996, 17 (12) :1203-1218

[4] Nanoengineering of inorganic and hybrid hollow spheres by colloidal templating [J].

Caruso, F ;

Caruso, RA ;

Möhwald, H .

SCIENCE, 1998, 282 (5391) :1111-1114

[5] Sacrificial Template-Directed Fabrication of Superparamagnetic Polymer Microcontainers for pH-Activated Controlled Release of Daunorubicin [J].

Chatzipavlidis, A. ;

Bilalis, P. ;

Efthimiadou, E. K. ;

Boukos, N. ;

Kordas, G. .

LANGMUIR, 2011, 27 (13) :8478-8485

[6] Preparation of narrow-disperse or monodisperse poly([poly(ethylene glycol) methyl ether acrylate]-co-(acrylic acid)} microspheres with ethyleneglycol dimethacrylate as crosslinker by distillation precipitation polymerization [J].

Dai, Zhao ;

Yang, Xinlin ;

Huang, Wenqiang .

POLYMER INTERNATIONAL, 2007, 56 (02) :224-230

[7] Preparation of DHAQ-loaded mPEG-PLGA-mPEG nanoparticles and evaluation of drug release behaviors in vitro/in vivo [J].

Duan, Yourong ;

Sun, Xun ;

Gong, Tao ;

Wang, Qi ;

Zhang, Zhirong .

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE, 2006, 17 (06) :509-516

[8] Cross-linked poly(methacrylic acid-co-poly(ethylene oxide) methyl ether methacrylate) microspheres and microgels prepared by precipitation polymerization:: A morphology study [J].

Goh, ECC ;

Stöver, HDH .

MACROMOLECULES, 2002, 35 (27) :9983-9989

[9] BIODEGRADABLE LONG-CIRCULATING POLYMERIC NANOSPHERES [J].

GREF, R ;

MINAMITAKE, Y ;

PERACCHIA, MT ;

TRUBETSKOY, V ;

TORCHILIN, V ;

LANGER, R .

SCIENCE, 1994, 263 (5153) :1600-1603

[10] Multilayers of a globular protein and a weak polyacid: Role of polyacid ionization in growth and decomposition in salt solutions [J].

Izumrudov, VA ;

Kharlampieva, E ;

Sukhishvili, SA .

BIOMACROMOLECULES, 2005, 6 (03) :1782-1788

← 1 2 →