The new provisional WHO entity 'RUNX1 mutated AML' shows specific genetics but no prognostic influence of dysplasia

被引：27

作者：

Haferlach, T. ^{[1
]}

Stengel, A. ^{[1
]}

Eckstein, S. ^{[1
]}

Perglerova, K. ^{[2
]}

Alpermann, T. ^{[1
]}

Kern, W. ^{[1
]}

Haferlach, C. ^{[1
]}

Meggendorfer, M. ^{[1
]}

机构：

[1] MLL Munich Leukemia Lab, Munich, Germany

[2] MLL2, Prague, Czech Republic

来源：

LEUKEMIA | 2016年 / 30卷 / 10期

关键词：

ACUTE MYELOID-LEUKEMIA; MUTATIONS; TRISOMY-13; CLASSIFICATION; ABNORMALITY;

D O I：

10.1038/leu.2016.150

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：2109 / 2112

页数：5

共 15 条

[1] AML with gain of chromosome 8 as the sole chromosomal abnormality (+8sole) is associated with a specific molecular mutation pattern including ASXL1 mutations in 46.8% of the patients [J].

Alpermann, Tamara ;

Haferlach, Claudia ;

Eder, Christiane ;

Nadarajah, Niroshan ;

Meggendorfer, Manja ;

Kern, Wolfgang ;

Haferlach, Torsten ;

Schnittger, Susanne .

LEUKEMIA RESEARCH, 2015, 39 (03) :265-272

[2] The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia [J].

Arber, Daniel A. ;

Orazi, Attilio ;

Hasserjian, Robert ;

Thiele, Jurgen ;

Borowitz, Michael J. ;

Le Beau, Michelle M. ;

Bloomfield, Clara D. ;

Cazzola, Mario ;

Vardiman, James W. .

BLOOD, 2016, 127 (20) :2391-2405

[3] PROPOSED REVISED CRITERIA FOR THE CLASSIFICATION OF ACUTE MYELOID-LEUKEMIA - A REPORT OF THE FRENCH-AMERICAN-BRITISH COOPERATIVE GROUP [J].

BENNETT, JM ;

CATOVSKY, D ;

DANIEL, MT ;

FLANDRIN, G ;

GALTON, DAG ;

GRALNICK, HR ;

SULTAN, C .

ANNALS OF INTERNAL MEDICINE, 1985, 103 (04) :620-625

[4] Age-Related Risk Profile and Chemotherapy Dose Response in Acute Myeloid Leukemia: A Study by the German Acute Myeloid Leukemia Cooperative Group [J].

Buechner, Thomas ;

Berdel, Wolfgang E. ;

Haferlach, Claudia ;

Haferlach, Torsten ;

Schnittger, Susanne ;

Mueller-Tidow, Carsten ;

Braess, Jan ;

Spiekermann, Karsten ;

Kienast, Joachim ;

Staib, Peter ;

Grueneisen, Andreas ;

Kern, Wolfgang ;

Reichle, Albrecht ;

Maschmeyer, Georg ;

Aul, Carlo ;

Lengfelder, Eva ;

Sauerland, Maria-Cristina ;

Heinecke, Achim ;

Woermann, Bernhard ;

Hiddemann, Wolfgang .

JOURNAL OF CLINICAL ONCOLOGY, 2009, 27 (01) :61-69

[5] Trisomy 13 is strongly associated with AML1/RUNX1 mutations and increased FLT3 expression in acute myeloid leukemia [J].

Dicker, Frank ;

Haferlach, Claudia ;

Kern, Wolfgang ;

Haferlach, Torsten ;

Schnittger, Susanne .

BLOOD, 2007, 110 (04) :1308-1316

[6] Acute Myeloid Leukemia [J].

Doehner, Hartmut ;

Weisdorf, Daniel J. ;

Bloomfield, Clara D. .

NEW ENGLAND JOURNAL OF MEDICINE, 2015, 373 (12) :1136-1152

[7] RUNX1 mutations in acute myeloid leukemia are associated with distinct clinico-pathologic and genetic features [J].

Gaidzik, V. I. ;

Teleanu, V. ;

Papaemmanuil, E. ;

Weber, D. ;

Paschka, P. ;

Hahn, J. ;

Wallrabenstein, T. ;

Kolbinger, B. ;

Koehne, C. H. ;

Horst, H. A. ;

Brossart, P. ;

Held, G. ;

Kuendgen, A. ;

Ringhoffer, M. ;

Goetze, K. ;

Rummel, M. ;

Gerstung, M. ;

Campbell, P. ;

Kraus, J. M. ;

Kestler, H. A. ;

Thol, F. ;

Heuser, M. ;

Schlegelberger, B. ;

Ganser, A. ;

Bullinger, L. ;

Schlenk, R. F. ;

Doehner, K. ;

Doehner, H. .

LEUKEMIA, 2016, 30 (11) :2160-2168

[8] RUNX1 Mutations in Acute Myeloid Leukemia: Results From a Comprehensive Genetic and Clinical Analysis From the AML Study Group [J].

Gaidzik, Verena I. ;

Bullinger, Lars ;

Schlenk, Richard F. ;

Zimmermann, Andreas S. ;

Roeck, Juergen ;

Paschka, Peter ;

Corbacioglu, Andrea ;

Krauter, Juergen ;

Schlegelberger, Brigitte ;

Ganser, Arnold ;

Spaeth, Daniela ;

Kuendgen, Andrea ;

Schmidt-Wolf, Ingo G. H. ;

Goetze, Katharina ;

Nachbaur, David ;

Pfreundschuh, Michael ;

Horst, Heinz A. ;

Doehner, Hartmut ;

Doehner, Konstanze .

JOURNAL OF CLINICAL ONCOLOGY, 2011, 29 (10) :1364-1372

[9]

GOASGUEN JE, 1992, LEUKEMIA, V6, P520

[10] Refinement of cytogenetic classification in acute myeloid leukemia: determination of prognostic significance of rare recurring chromosomal abnormalities among 5876 younger adult patients treated in the United Kingdom Medical Research Council trials [J].

Grimwade, David ;

Hills, Robert K. ;

Moorman, Anthony V. ;

Walker, Helen ;

Chatters, Stephen ;

Goldstone, Anthony H. ;

Wheatley, Keith ;

Harrison, Christine J. ;

Burnett, Alan K. .

BLOOD, 2010, 116 (03) :354-365

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