Syntheses and preliminary pharmacological evaluation of the two epimers of the 5-F2t-isoprostane

被引：21

作者：

Durand, T

Cracowski, JL

Guy, A

Rossi, JC

机构：

[1] Univ Montpellier I, Fac Pharm, CNRS, UMR 5074, F-34060 Montpellier 2, France

[2] Fac Med Grenoble, Pharmacol Lab, F-38706 La Tronche, France

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(01)00473-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The total synthesis of the 5-F-2t-isoprostane I and its 5-epimer 2 from diacetone-D-glucose is described. We report preliminary data on the vascular properties of these compounds. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：2495 / 2498

页数：4

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