Palladium Catalyzed Stereoselective C-Glycosylation of Glycals with Enol Triflates

被引：31

作者：

Bai, Yaguang ^{[1
]}

Leow, Minli ^{[1
]}

Zeng, Jing ^{[1
]}

Liu, Xue-Wei ^{[1
]}

机构：

[1] Nanyang Technol Univ, Div Chem & Biol Chem, Sch Phys & Math Sci, Singapore 637371, Singapore

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 20期

关键词：

BETA-HETEROATOM ELIMINATION; MECHANISTIC INSIGHTS; ARYLBORONIC ACIDS; ARYL IODIDES; STEREOCHEMISTRY; GLYCOSIDATION; AZIRIDINATION; KETONES;

D O I：

10.1021/ol202368n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient palladium catalyzed C-glycosylation of glycals with enol triflates has been established. The coupling reactions took place on the anomeric carbon, and the coupling products gave exclusively a isomers. The flexibility of the reaction was exemplified by the broad spectra of substrate scope, constituted of glycals protected with good leaving groups as well as an assortment of enol triflates.

引用

页码：5648 / 5651

页数：4

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