Acute lymphoblastic leukemia and developmental biology A crucial interrelationship

被引：18
作者：
Campos-Sanchez, Elena [2 ]
Toboso-Navasa, Amparo [2 ]
Romero-Camarero, Isabel [1 ]
Barajas-Diego, Marcos [1 ]
Sanchez-Garcia, Isidro [1 ]
Cobaleda, Cesar [2 ]
机构：
[1] Univ Salamanca, Expt Therapeut & Translat Oncol Program, Inst Biol Mol & Celular Canc, CSIC, E-37008 Salamanca, Spain
[2] Univ Autonoma Madrid, Ctr Biol Mol Severo Ochoa, CSIC, Madrid, Spain
来源：
CELL CYCLE | 2011年 / 10卷 / 20期
关键词：
leukemia; hematopoietic development; leukemic stem cells; lymphopoiesis; developmental plasticity; B-cells; stem cells; cancer; B-ALL; B-CELL FACTOR; MURINE HEMATOPOIETIC STEM; COMMON LYMPHOID PROGENITORS; TRANSCRIPTION FACTOR E2A; SELF-RENEWAL; LONG-TERM; GENE-EXPRESSION; PRO-B; CHROMOSOME TRANSLOCATIONS; HOMEODOMAIN PROTEIN;
D O I：
10.4161/cc.10.20.17779
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The latest scientific findings in the field of cancer research are redefining our understanding of the molecular and cellular basis of the disease, moving the emphasis toward the study of the mechanisms underlying the alteration of the normal processes of cellular differentiation. The concepts best exemplifying this new vision are those of cancer stem cells and tumoral reprogramming. The study of the biology of acute lymphoblastic leukemias (ALLs) has provided seminal experimental evidences supporting these new points of view. Furthermore, in the case of B-cells, it has been shown that all the stages of their normal development show a tremendous degree of plasticity, allowing them to be reprogrammed to other cellular types, either normal or leukemic. Here we revise the most recent discoveries in the fields of B-cell developmental plasticity and B-ALL research, and discuss their interrelationships and their implications for our understanding of the biology of the disease.
引用
收藏
页码：3473 / 3486
页数：14
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