Gut Microbiota and Parkinson's Disease: Implications for Faecal Microbiota Transplantation Therapy

被引:20
作者
Kang, Yongbo [1 ]
Kang, Xing [1 ]
Zhang, Hongfang [1 ]
Liu, Qingqing [1 ]
Yang, Hao [1 ]
Fan, Weiping [1 ]
机构
[1] Shanxi Med Univ, Sch Basic Med Sci, Dept Microbiol & Immunol, Taiyuan, Shanxi, Peoples R China
基金
山西省青年科学基金;
关键词
gut microbiota; Parkinson's disease; gut-microbiota-brain axis; brain-gut axis; inflammation; faecal microbiota transplantation; BRAIN AXIS; HYDROGEN-SULFIDE; PATHOGENESIS; MODEL; OBESITY; BOWEL;
D O I
10.1177/17590914211016217
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Parkinson's disease (PD) ranks the second place among neurodegenerative diseases in terms of its morbidity, which affects 1 - 2% people aged over 65 years. In addition to genetics, some environmental factors may exert vital parts in PD occurrence as well. At present, more and more studies are conducted to elucidate the association between gut microbial dysbiosis and the incidence of PD. Gut microbial dysbiosis has a certain effect on both the central nervous system (CNS) and the enteric nervous system (ENS), which indicates that there is a gut-microbiota-brain axis that induces CNS disorders. Some gut microbial strains are suggested to suppress or weaken the neuroinflammation- and gut-inflammation-immune responses, which suggests the protective and pathogenic effects of certain gut microbial species on PD progression. Therefore, gut microbiome may contain plenty of targets for preventing and managing PD. Faecal microbiota transplantation (FMT) may serve as a direct and useful treatment for PD in the future. Nonetheless, there is little available scientific research in this field. The present work reviewed the latest research to examine the association of gut microbiota with PD, and the future prospects of FMT treatment.
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页数:10
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