Inhibitory action of telithromycin against Shiga toxin and endotoxin

被引：9

作者：

Nakagawa, S ^{[1
]}

Kojio, S ^{[1
]}

Taneike, I ^{[1
]}

Iwakura, N ^{[1
]}

Tamura, Y ^{[1
]}

Kushiya, K ^{[1
]}

Gondaira, F ^{[1
]}

Yamamoto, T ^{[1
]}

机构：

[1] Niigata Univ, Grad Sch Med & Dent Sci, Div Bacteriol, Dept Infect Dis Control & Int Med, Niigata, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 310卷 / 04期

关键词：

telithromycin; Escherichia coli; phage; shiga toxin; endotoxin; cytokine;

D O I：

10.1016/j.bbrc.2003.09.145

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Shiga toxin (Stx)-producing Escherichia coli (STEC) is associated with hemolytic uremic syndrome (HUS). High inflammatory cytokine [interleukin (IL)-6 and IL-8] levels and low anti-inflammatory cytokine (IL-10) levels are indicators of a high risk for developing HUS in STEC-infected children. In this study, we investigated inhibitory action of telithromycin, a ketolide, against STEC and against Six and lipopolysaccharide (LPS). Telithromycin inhibited in vitro STEC growth without inducing Stx phage, in marked contrast to norfloxacin. Six markedly induced inflammatory (but not anti-inflammatory) cytokine production in human peripheral blood monocytes, while LIPS induced both inflammatory and anti-inflammatory cytokine production. Telithromycin selectively inhibited the IL-6 and IL-8 production from Stx-stimulated (but not LPS-stimulated) monocytes. The drug did not significantly inhibit IL-10 production. Our data suggest that Six plays a crucial role in the stimulation of inflammatory cytokines and such inflammatory response is inhibited by telithromycin, an anti-bacterial agent. (C) 2003 Elsevier Inc. All rights reserved.

引用

页码：1194 / 1199

页数：6

共 31 条

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