Selenium in Human Health and Disease

被引:1031
作者
Fairweather-Tait, Susan J. [1 ]
Bao, Yongping [1 ]
Broadley, Martin R. [2 ]
Collings, Rachel [1 ]
Ford, Dianne [3 ]
Hesketh, John E. [3 ]
Hurst, Rachel [1 ]
机构
[1] Univ E Anglia, Sch Med Hlth Policy & Practice, Norwich NR4 7TJ, Norfolk, England
[2] Univ Nottingham, Sch Biosci, Loughborough, Leics, England
[3] Newcastle Univ, Sch Med, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
基金
英国生物技术与生命科学研究理事会;
关键词
GLUTATHIONE-PEROXIDASE ACTIVITY; GENE-EXPRESSION PROFILES; MANGANESE SUPEROXIDE-DISMUTASE; SINGLE-NUCLEOTIDE POLYMORPHISM; NUTRITION INTERVENTION TRIALS; BASE-LINE CHARACTERISTICS; FOOD-CHAIN SELENIUM; KASHIN-BECK-DISEASE; BREAST-CANCER RISK; HPLC-ICP-MS;
D O I
10.1089/ars.2010.3275
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
This review covers current knowledge of selenium in the environment, dietary intakes, metabolism and status, functions in the body, thyroid hormone metabolism, antioxidant defense systems and oxidative metabolism, and the immune system. Selenium toxicity and links between deficiency and Keshan disease and Kashin-Beck disease are described. The relationships between selenium intake/status and various health outcomes, in particular gastrointestinal and prostate cancer, cardiovascular disease, diabetes, and male fertility, are reviewed, and recent developments in genetics of selenoproteins are outlined. The rationale behind current dietary reference intakes of selenium is explained, and examples of differences between countries and/or expert bodies are given. Throughout the review, gaps in knowledge and research requirements are identified. More research is needed to improve our understanding of selenium metabolism and requirements for optimal health. Functions of the majority of the selenoproteins await characterization, the mechanism of absorption has yet to be identified, measures of status need to be developed, and effects of genotype on metabolism require further investigation. The relationships between selenium intake/status and health, or risk of disease, are complex but require elucidation to inform clinical practice, to refine dietary recommendations, and to develop effective public health policies. Antioxid. Redox Signal. 14, 1337-1383.
引用
收藏
页码:1337 / 1383
页数:47
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