1,2,5,6-tetra-O-benzyl-D-mannitol derivatives as novel HIV protease inhibitors

被引：8

作者：

Bouzide, A ^{[1
]}

Sauvé, G ^{[1
]}

Sévigny, G ^{[1
]}

Yelle, J ^{[1
]}

机构：

[1] Pharmacor Inc, Laval, PQ H7V 3S8, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 20期

关键词：

D O I：

10.1016/S0960-894X(03)00677-2

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis and structure-activity relationships of HIV protease inhibitors derived from carbohydrate alditols are discussed. We disclose a new series of 1,2,5,6-tetra-O-alkyl-D-mannitol exhibiting sub-micromolar activity against HIV-protease. This series of inhibitors are non-nitrogen containing HIV-protease inhibitors and they are readily prepared in a few chemical steps from inexpensive commercially available starting materials. (C) 2003 Published by Elsevier Ltd.

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页码：3601 / 3605

页数：5

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