Partial electroosmotic pumping in complex capillary systems -: Part 2:: Fabrication and application of a micro total analysis system (μTAS) suited for continuous volumetric nanotitrations

被引：57

作者：

Guenat, OT ^{[1
]}

Ghiglione, D ^{[1
]}

Morf, WE ^{[1
]}

de Rooij, NF ^{[1
]}

机构：

[1] Univ Neuchatel, Inst Microtechnol, Sensors Actuators & Microsyst Lab, CH-2007 Neuchatel, Switzerland

来源：

SENSORS AND ACTUATORS B-CHEMICAL | 2001年 / 72卷 / 03期

关键词：

nanopump; electroosmotic flow; micromixer; potentiometric detection;

D O I：

10.1016/S0925-4005(00)00674-2

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

A new micro total analysis system (mu TAS) designed for volumetric nanotitrations, integrating two electroosmotically driven nanopumps and a sensor unit, is presented. The unique feature of the integrated electroosmotic pumps is their ability to pump widely different solutions, independent of intrinsic characteristics such as pH or ionic strength, with the exception of viscosity. Typical flow rates achieved are in the range of 2-65 nl/s, depending on the number of microchannels connected in parallel and on the applied voltage. The pulsation-free Rows developed in two nanopumps push out the solutions contained in two reservoirs. The solutions are fed into a three-dimensional mixer, where the chemical reaction takes place. The potential difference as a function of the sample concentration is detected by means of a pseudo-reference electrode located in one channel and an indicator electrode placed downstream from the mixer in the sensor unit. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：273 / 282

页数：10

共 19 条

[11]

LARSEN UD, MU TAS BAS SWITZ, P228

[12]

MANZ A, P MU TAS 98 BANFF CA, P235

[13]

MENSINGER H, P MU TAS 94 NETH, P237

[14]

MIYAKE R, P MEMS 93 FORT LAUD, P248