Chemical and pharmacological examination of antinociceptive constituents of Wedelia paludosa

被引：70

作者：

Block, LC

Santos, ARS

de Souza, MM

Scheidt, C

Yunes, RA

Santos, MA

Delle Monache, F

Cechinel, V ^{[1
]}

机构：

[1] Univ Vale Itajai, FAQFAR, NIQFAR, BR-88302202 Itajai, SC, Brazil

[2] Univ Fed Santa Catarina, Dept Quim, BR-88049900 Florianopolis, SC, Brazil

[3] Univ Salamanca, Dept Quim, E-37008 Salamanca, Spain

[4] CNR, Ctr Chim Recettori, Rome, Italy

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 1998年 / 61卷 / 01期

关键词：

Wedelia paludosa; folk medicine; antinociception; writhing test; kaurenoic acid; luteolin;

D O I：

10.1016/S0378-8741(98)00019-1

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The present work describes the antinociceptive effects of some fractions and two pure compounds obtained from the Wedelia paludosa, a Brazilian medicinal plant employed in folk medicine against a variety of diseases, including dolorous pathologies. It was found that such fractions as well as kaurenoic acid and luteolin exhibit marked antinociceptive action in mice using acetic acid-induced writhing. They were more active than some well-known analgesic drugs, such as acetyl salicylic acid, acetaminophen, dipyrone and indomethacin. The results confirm our previous studies conducted with this plant, suggesting that different chemical constituents are responsible for the antinociceptive activity shown by the extracts and fractions prepared from W. paludosa. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：85 / 89

页数：5

共 27 条

[1] EFFECTS OF THE FLAVONE LUTEOLIN, ISOLATED FROM COLCHICUM-RICHII, ON GUINEA-PIG ISOLATED SMOOTH-MUSCLE AND HEART AND ON BLOOD-PRESSURE AND BLOOD-FLOW [J].