Prognostic and predictive biomarkers in renal cell carcinoma

被引：17

作者：

Vickers, Michael M. ^{[1
]}

Heng, Daniel Y. C. ^{[1
]}

机构：

[1] Univ Calgary, Dept Oncol, Tom Baker Canc Ctr, Calgary, AB T2N 4N2, Canada

来源：

TARGETED ONCOLOGY | 2010年 / 5卷 / 02期

关键词：

Biomarkers; Renal cell carcinoma; von Hippel-Lindau (VHL); Vascular endothelial growth factor (VEGF); Hypoxia-inducible factor (HIF); Carbonic anhydrase IX (CAIX); CARBONIC-ANHYDRASE-IX; ENDOTHELIAL GROWTH-FACTOR; HIPPEL-LINDAU GENE; HYPOXIA-INDUCIBLE FACTOR-1-ALPHA; INTEGRATED STAGING SYSTEM; KIDNEY CANCER; VHL GENE; TUMOR AGGRESSIVENESS; INDEPENDENT PREDICTOR; RADICAL NEPHRECTOMY;

D O I：

10.1007/s11523-010-0143-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With the recent advances in targeted therapies, biomarkers in renal cell carcinoma (RCC) continue to be developed. Historically, information regarding prognosis has come from clinicopathologic variables, however in recent years much research has focused on the molecular basis of renal cell cancer. The discovery of reliable biomarkers in RCC could have an important impact on diagnosis, prognosis, and prediction of therapeutic benefit. To date, most biomarker research has centered on byproducts of the von Hippel-Lindau (VHL) pathway including VHL mutations, vascular endothelial growth factor (ligands and receptors), hypoxia-inducible factor, and carbonic anhydrase IX. This review examines these potential biomarkers, biomarker prognostic models, and molecular expression profiles in the field of renal cell carcinoma.

引用

页码：85 / 94

页数：10

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