Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization:: An efficient synthesis of Praziquantel

被引：53

作者：

Kim, JH ^{[1
]}

Lee, YS ^{[1
]}

Park, H ^{[1
]}

Kim, CS ^{[1
]}

机构：

[1] Korea Inst Sci & Technol, Div Appl Sci, Seoul 130650, South Korea

来源：

TETRAHEDRON | 1998年 / 54卷 / 26期

关键词：

D O I：

10.1016/S0040-4020(98)00401-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient synthesis of pyrazinoisoquinoline derivatives including Praziquantel has been accomplished by the tandem amidoalkylaion and N-acyliminium ion cyclization of amido-acetals. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：7395 / 7400

页数：6

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