The effects of Caulerpa microphysa enzyme-digested extracts on ACE-inhibitory activity and in vitro anti-tumour properties

被引：22

作者：

Lin, Hui-Chiu ^{[2
]}

Chou, Su-Tze ^{[3
]}

Chuang, Mei-Yu ^{[3
]}

Liao, Tzu-Yen ^{[2
]}

Tsai, Wann-Sheng ^{[2
]}

Chiu, Tsai-Hsin ^{[1
]}

机构：

[1] Natl PengHu Univ Sci & Technol, Dept Food Sci, Makung City 880, Penghu County, Taiwan

[2] EY, COA, Penghu Marine Biol Res Ctr, Fisheries Res Inst, Makung City 880, Penghu County, Taiwan

[3] Providence Univ, Dept Food & Nutr, Taichung 43301, Taiwan

来源：

FOOD CHEMISTRY | 2012年 / 134卷 / 04期

关键词：

Caulerpa microphysa; Inhibited angiotensin converting enzyme; Anti-cancer ability; ANTIHYPERTENSIVE ACTIVITY; ANTIOXIDANT ACTIVITIES; DNA-DAMAGE; ANGIOTENSIN; PEPTIDE; ALGAE; SEAWEEDS; PROTEIN; WAKAME; JEJU;

D O I：

10.1016/j.foodchem.2012.04.105

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The aim of this study was to determine the ACE inhibitory activity and its anti-cancer properties of Caulerpa microphysa extracts. C. microphysa samples were digested with Flavourzyme, Alcalase, and pepsin. The ACE inhibitory activity of enzyme-digested C microphysa decreased in the order of digestion with pepsin > Flavourzyme > Alcalase; that is, pepsin-extracted samples had significantly higher activity than the other enzyme extractions. To test its anti-tumour effects in vitro C microphysa pepsin-digested extracts were applied to BALB/c mice with transplanted myelomonocytic leukaemia (WEHI-3) and Human promyelocytic leukaemia (HL-60) cell lines. The growth of both cell lines was inhibited, and extracts induced DNA damage, evaluated with a comet assay. The data demonstrate that C microphysa pepsin-digested extract had the ability to anti-tumour effects. Further application as a health food is worthy of investigation. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2235 / 2241

页数：7

共 3 条

[1] Production of angiotensin-I-converting enzyme (ACE) inhibitory activity in milk fermented with probiotic strains: Effects of calcium, pH and peptides on the ACE-inhibitory activity
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INTERNATIONAL DAIRY JOURNAL, 2011, 21 (09) : 615 - 622
[2] Effects of season and management on fatty acid profile, ACE-inhibitory activity and anti-oxidant properties of Italian Alpine cheeses
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ITALIAN JOURNAL OF ANIMAL SCIENCE, 2022, 21 (01) : 1021 - 1033
[3] Vascular effects, angiotensin I-converting enzyme (ACE)-inhibitory activity, and anti hypertensive properties of peptides derived from egg white
Miguel, Marta
Manso, Maria
Aleixandre, Amaya
Alonso, Maria Jesus
Salaices, Mercedes
Lopez-Fandino, Rosina
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2007, 55 (26) : 10615 - 10621

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