Effects of psychopharmacological treatment with antipsychotic drugs on the vascular system

被引：28

作者：

Kahl, Kai G. ^{[1
,2
]}

Westhoff-Bleck, Mechthild ^{[3
]}

Krueger, Tillmann H. C. ^{[1
]}

机构：

[1] Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany

[2] AGNP, Working Grp Polypharm, Munich, Germany

[3] Dept Cardiol & Angiol, Hannover, Germany

来源：

VASCULAR PHARMACOLOGY | 2018年 / 100卷

关键词：

Cardiovascular effects; Vascular system; Antidepressants; Antipsychotics; Morbidity; Mortality; QTc prolongation; Weight gain; Diabetes; CORRECTED QT INTERVAL; SEVERE MENTAL-ILLNESS; EXCESS MORTALITY; VENOUS THROMBOEMBOLISM; ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR RISK; CEREBROVASCULAR EVENTS; ELDERLY-PATIENTS; ADVERSE EVENTS; BLOOD-PRESSURE;

D O I：

10.1016/j.vph.2017.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Psychopharmacological treatment with antipsychotic drugs is an essential part of guideline-based treatment strategies in psychotic disorders, such as schizophrenia, schizoaffective disorders, and delusional disorders. Other mental disorders frequently treated with antipsychotic drugs are bipolar disorders, and major depressive disorder. Furthermore, antipsychotic drugs are often given in emergency and surgical units for the treatment of metabolic or postoperative delirium. Antipsychotic drugs can exert direct and indirect effects on the vascular system, potentially leading to severe complications such as thromboembolism. Therefore, knowledge of vascular side effects of antipsychotic drugs is important for clinicians. This clinical orientated review article covers direct and indirect effects of antipsychotics on the vascular system.

引用

页码：20 / 25

页数：6

共 129 条

[71] Excess mortality in persons with severe mental disorders: a multilevel intervention framework and priorities for clinical practice, policy and research agendas [J].

Liu, Nancy H. ;

Daumit, Gail L. ;

Dua, Tarun ;

Aquila, Ralph ;

Charlson, Fiona ;

Cuijpers, Pim ;

Druss, Benjamin ;

Dudek, Kenn ;

Freeman, Melvyn ;

Fujii, Chiyo ;

Gaebel, Wolfgang ;

Hegerl, Ulrich ;

Levav, Itzhak ;

Laursen, Thomas Munk ;

Ma, Hong ;

Maj, Mario ;

Elena Medina-Mora, Maria ;

Nordentoft, Merete ;

Prabhakaran, Dorairaj ;

Pratt, Karen ;

Prince, Martin ;

Rangaswamy, Thara ;

Shiers, David ;

Susser, Ezra ;

Thornicroft, Graham ;

Wahlbeck, Kristian ;

Wassie, Abe Fekadu ;

Whiteford, Harvey ;

Saxena, Shekhar .

WORLD PSYCHIATRY, 2017, 16 (01) :30-40

[72] Excess Mortality in Patients with Severe Mental Disorders in 1996-2010 in Finland [J].

Lumme, Sonja ;

Pirkola, Sami ;

Manderbacka, Kristiina ;

Keskimaki, Ilmo .

PLOS ONE, 2016, 11 (03)

[73] Fatality due to amisulpride toxicity: a case report [J].

Lynch, Matthew J. ;

Woods, Jessica ;

George, Natalia ;

Gerostamoulos, Dimitri .

MEDICINE SCIENCE AND THE LAW, 2008, 48 (02) :173-177

[74] Effect of cytochrome P450 3A4 inhibitor ketoconazole on risperidone pharmacokinetics in healthy volunteers [J].

Mahatthanatrakul, W. ;

Sriwiriyajan, S. ;

Ridtitid, W. ;

Boonleang, J. ;

Wongnawa, M. ;

Rujimamahasan, N. ;

Pipatrattanaseree, W. .

JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS, 2012, 37 (02) :221-225

[75] Effects of hepatic or renal impairment on the pharmacokinetics of aripiprazole [J].

Mallikaarjun, Suresh ;

Shoaf, Susan E. ;

Boulton, David W. ;

Bramer, Steven L. .

CLINICAL PHARMACOKINETICS, 2008, 47 (08) :533-542

[76] Assessment of risk of venous thromboembolism and its possible prevention in psychiatric patients [J].

Maly, Radovan ;

Masopust, Jiri ;

Hosak, Ladislav ;

Konupcikova, Katerina .

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2008, 62 (01) :3-8

[77] Life tables for patients with mental disease [J].

Malzberg, B .

JOURNAL OF THE AMERICAN STATISTICAL ASSOCIATION, 1932, 27 (177A) :160-174

[78] Two cases of deep vein thrombosis associated with antipsychotic drug use [J].

Matsumoto, M ;

Konno, T ;

Tamba, K ;

Abe, T ;

Kato, S ;

Kajii, E .

PSYCHIATRY AND CLINICAL NEUROSCIENCES, 2004, 58 (04) :450-451

[79]

Mauri MC, 2014, EXCLI J, V13, P1163

[80] Clinical pharmacokinetics of atypical antipsychotics - A critical review of the relationship between plasma concentrations and clinical response [J].

Mauri, Massimo C. ;

Volonteri, Lucia S. ;

Colasanti, Alessandro ;

Fiorentini, Alessio ;

De Gaspari, Ilaria F. ;

Bareggi, Silvio R. .

CLINICAL PHARMACOKINETICS, 2007, 46 (05) :359-388

← 3 4 5 6 7 8 9 10 11 12 →