Effects of psychopharmacological treatment with antipsychotic drugs on the vascular system

被引：28

作者：

Kahl, Kai G. ^{[1
,2
]}

Westhoff-Bleck, Mechthild ^{[3
]}

Krueger, Tillmann H. C. ^{[1
]}

机构：

[1] Med Sch, Dept Psychiat Social Psychiat & Psychotherapy, Hannover, Germany

[2] AGNP, Working Grp Polypharm, Munich, Germany

[3] Dept Cardiol & Angiol, Hannover, Germany

来源：

VASCULAR PHARMACOLOGY | 2018年 / 100卷

关键词：

Cardiovascular effects; Vascular system; Antidepressants; Antipsychotics; Morbidity; Mortality; QTc prolongation; Weight gain; Diabetes; CORRECTED QT INTERVAL; SEVERE MENTAL-ILLNESS; EXCESS MORTALITY; VENOUS THROMBOEMBOLISM; ATYPICAL ANTIPSYCHOTICS; CARDIOVASCULAR RISK; CEREBROVASCULAR EVENTS; ELDERLY-PATIENTS; ADVERSE EVENTS; BLOOD-PRESSURE;

D O I：

10.1016/j.vph.2017.09.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Psychopharmacological treatment with antipsychotic drugs is an essential part of guideline-based treatment strategies in psychotic disorders, such as schizophrenia, schizoaffective disorders, and delusional disorders. Other mental disorders frequently treated with antipsychotic drugs are bipolar disorders, and major depressive disorder. Furthermore, antipsychotic drugs are often given in emergency and surgical units for the treatment of metabolic or postoperative delirium. Antipsychotic drugs can exert direct and indirect effects on the vascular system, potentially leading to severe complications such as thromboembolism. Therefore, knowledge of vascular side effects of antipsychotic drugs is important for clinicians. This clinical orientated review article covers direct and indirect effects of antipsychotics on the vascular system.

引用

页码：20 / 25

页数：6

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