Predominance of KPC-3 in a Survey for Carbapenemase-Producing Enterobacteriaceae in Portugal

被引：39
作者：
Manageiro, Vera [1 ,2 ]
Ferreira, Eugenia [1 ]
Almeida, Joana [1 ]
Barbosa, Stephanie [1 ]
Simoes, Constanca [1 ]
Bonomo, Robert A. [3 ]
Canica, Manuela [1 ]
机构：
[1] Natl Inst Hlth Dr Ricardo Jorge, Dept Infect Dis, Natl Reference Lab Antibiot Resistances & Healthc, Lisbon, Portugal
[2] Univ Porto, CECA ICETA, Ctr Estudos Ciencia Anim, P-4100 Oporto, Portugal
[3] Case Western Reserve Univ, Dept Med Pharmacol Mol Biol & Microbiol, Louis Stokes Cleveland VA Med Ctr, Res Serv, Cleveland, OH 44106 USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2015年 / 59卷 / 06期
基金：
美国国家卫生研究院;
关键词：
METALLO-BETA-LACTAMASES; CLASS; 3; INTEGRON; KLEBSIELLA-PNEUMONIAE; SPREAD; EVOLUTION; PLASMIDS;
D O I：
10.1128/AAC.05065-14
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Among the 2,105 Enterobacteriaceae tested in a survey done in Portugal, 165 were nonsusceptible to carbapenems, from which 35 (26 Klebsiella pneumoniae, 3 Escherichia coli, 2 Enterobacter aerogenes, and 3 Enterobacter cloacae isolates and 1 Klebsiella oxytoca isolate) were confirmed to be carbapenemase producers by the presence of 30 Tn4401d-bla(KPC-3), 4 intI3-bla(GES-5), and one intI1-bla(VIM-2) gene, alone or in combination with other bla genes. The dissemination of bla(KPC-3) gene carried by an IncF plasmid suggests lateral gene transfer as a major mechanism of dissemination.
引用
收藏
页码：3588 / 3592
页数：5
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