The Role of Selected Chemokines and Their Receptors in the Development of Gliomas

被引：87

作者：

Groblewska, Magdalena ^{[1
]}

Litman-Zawadzka, Ala ^{[2
]}

Mroczko, Barbara ^{[1
,2
]}

机构：

[1] Univ Hosp Bialystok, Dept Biochem Diagnost, PL-15269 Bialystok, Poland

[2] Med Univ Bialystok, Dept Neurodegenerat Diagnost, PL-15269 Bialystok, Poland

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2020年 / 21卷 / 10期

关键词：

glioma; central nervous system tumor; chemokine; conventional chemokine receptor; atypical chemokine receptor; angiogenesis; inflammation; leukocyte; MONOCYTE CHEMOATTRACTANT PROTEIN-1; TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL GROWTH-FACTOR; DUFFY ANTIGEN RECEPTOR; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; LOW-GRADE GLIOMA; CC-CHEMOKINE; GLIOBLASTOMA-MULTIFORME; DENDRITIC CELL;

D O I：

10.3390/ijms21103704

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Among heterogeneous primary tumors of the central nervous system (CNS), gliomas are the most frequent type, with glioblastoma multiforme (GBM) characterized with the worst prognosis. In their development, certain chemokine/receptor axes play important roles and promote proliferation, survival, metastasis, and neoangiogenesis. However, little is known about the significance of atypical receptors for chemokines (ACKRs) in these tumors. The objective of the study was to present the role of chemokines and their conventional and atypical receptors in CNS tumors. Therefore, we performed a thorough search for literature concerning our investigation via the PubMed database. We describe biological functions of chemokines/chemokine receptors from various groups and their significance in carcinogenesis, cancer-related inflammation, neo-angiogenesis, tumor growth, and metastasis. Furthermore, we discuss the role of chemokines in glioma development, with particular regard to their function in the transition from low-grade to high-grade tumors and angiogenic switch. We also depict various chemokine/receptor axes, such as CXCL8-CXCR1/2, CXCL12-CXCR4, CXCL16-CXCR6, CX3CL1-CX3CR1, CCL2-CCR2, and CCL5-CCR5 of special importance in gliomas, as well as atypical chemokine receptors ACKR1-4, CCRL2, and PITPMN3. Additionally, the diagnostic significance and usefulness of the measurement of some chemokines and their receptors in the blood and cerebrospinal fluid (CSF) of glioma patients is also presented.

引用

页数：52

共 367 条

[1] The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity [J].

Addison, CL ;

Daniel, TO ;

Burdick, MD ;

Liu, H ;

Ehlert, JE ;

Xue, YY ;

Buechi, L ;

Walz, A ;

Richmond, A ;

Strieter, RM .

JOURNAL OF IMMUNOLOGY, 2000, 165 (09) :5269-5277

[2] Overexpression of the duffy antigen receptor for chemokines (DARC) by NSCLC tumor cells results in increased tumor necrosis [J].

Addison, CL ;

Belperio, JA ;

Burdick, MD ;

Strieter, RM .

BMC CANCER, 2004, 4 (1)

[3] Role of endothelial progenitors and other bone marrow-derived cells in the development of the tumor vasculature [J].

Ahn, G-One ;

Brown, J. Martin .

ANGIOGENESIS, 2009, 12 (02) :159-164

[4] Necrotic cells influence migration and invasion of glioblastoma via NF-κB/AP-1-mediated IL-8 regulation [J].

Ahn, So-Hee ;

Park, Hyunju ;

Ahn, Young-Ho ;

Kim, Sewha ;

Cho, Min-Sun ;

Kang, Jihee Lee ;

Choi, Youn-Hee .

SCIENTIFIC REPORTS, 2016, 6

[5] The chemokines CCR1 and CCRL2 have a role in colorectal cancer liver metastasis [J].

Akram, Israa G. ;

Georges, Rania ;

Hielscher, Thomas ;

Adwan, Hassan ;

Berger, Martin R. .

TUMOR BIOLOGY, 2016, 37 (02) :2461-2471

[6] Transendothelial migration of CD16+ monocytes in response to fractalkine under constitutive and inflammatory conditions [J].

Ancuta, P ;

Moses, A ;

Gabuzda, D .

IMMUNOBIOLOGY, 2004, 209 (1-2) :11-20

[7] CXCR2-Expressing Tumor Cells Drive Vascular Mimicry in Antiangiogenic Therapy-Resistant Glioblastoma [J].

Angara, Kartik ;

Borin, Thaiz F. ;

Rashid, Mohammad H. ;

Lebedyeva, Iryna ;

Ara, Roxan ;

Lin, Ping-Chang ;

Iskander, A. S. M. ;

Bollag, Roni J. ;

Achyut, Bhagelu R. ;

Arbab, Ali S. .

NEOPLASIA, 2018, 20 (10) :1070-1082

[8] HUMAN INTERFERON-INDUCIBLE PROTEIN-10 IS A POTENT INHIBITOR OF ANGIOGENESIS IN-VIVO [J].

ANGIOLILLO, AL ;

SGADARI, C ;

TAUB, DD ;

LIAO, F ;

FARBER, JM ;

MAHESHWARI, S ;

KLEINMAN, HK ;

REAMAN, GH ;

TOSATO, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 182 (01) :155-162

[9] Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness [J].

Antonio Sanchez-Alcaniz, Juan ;

Haege, Sammy ;

Mueller, Wiebke ;

Pla, Ramon ;

Mackay, Fabienne ;

Schulz, Stefan ;

Lopez-Bendito, Guillermina ;

Stumm, Ralf ;

Marin, Oscar .

NEURON, 2011, 69 (01) :77-90

[10] The murine CC chemokine, 6C-kine, inhibits tumor growth and angiogenesis in a human lung cancer SCID mouse model [J].

Arenberg, DA ;

Zlotnick, A ;

Strom, SRB ;

Burdick, MD ;

Strieter, RM .

CANCER IMMUNOLOGY IMMUNOTHERAPY, 2001, 49 (11) :587-592

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